Mental Health

History of mistrust complicates study of dementia in African-Americans

August 08, 2017

The question came as a shock to Dorothy Reeves: Would she be willing to donate her husband's brain for research?

She knew dementia would steadily take Levi Reeves' memories of their 57-year marriage, his remaining lucidity and, eventually, his life. But to let scientists take his brain after he died? That seemed too much to ask.  

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Mice made with CRISPR usher in new era of autism research

August 07, 2017

Researchers have debuted two mouse models of autism made using the gene-editing tool CRISPR. Both strains lack one functional copy of CHD8, a gene with strong ties to autism.

CRISPR allows researchers to quickly and efficiently insert specific mutations into single-cell mouse embryos. Several teams have used the method to make mouse models for other conditions, including Rett syndrome, an autism-related condition. The new mice represent the first use of the method to make models expressly for autism.

Why are Alzheimer’s Rates So High Among Latinos?

August 04, 2017

Latinos are California’s fastest-growing ethnic group. They’re also among the most likely to develop Alzheimer’s disease. A new five-year study out of UC Davis will investigate why.

The study grew out of a $14.7 million grant from the National Institutes of Health. It will involve nine other universities and last for five years.

Rates of dementia in Latino adults are about 1.5 times higher than rates in white adults. They are slightly lower than the rates in the African American community.

UC Davis to co-lead $14.7 million study of dementia in U.S. Hispanics

July 25, 2017

A UC Davis neurology researcher will share the lead in a $14.7 million, multiyear study examining the causes of Alzheimer's disease and other forms of dementia among Latinos in the United States, university officials announced Tuesday. The work is being funded by the National Institutes of Health.

Charles S. DeCarli, director of the UC Davis Alzheimer’s Disease Center, will serve as co-principal investigator along with Hector M. Gonzalez, an associate professor of epidemiology and biostatistics at Michigan State University. 

Mice Provide Insight Into Genetics of Autism Spectrum Disorders

June 26, 2017

While the definitive causes remain unclear, several genetic and environmental factors increase the likelihood of autism spectrum disorder, or ASD, a group of conditions covering a “spectrum” of symptoms, skills and levels of disability.