The riddle of CHD8 haploinsufficiency in autism spectrum disorder

Autism spectrum disorders (ASDs) are a group of neurodevelopmental conditions defined by social and communication deficits accompanied by repetitive and stereotyped behaviors. The core symptoms of ASDs are rarely isolated and most often coexist with other conditions, such as intellectual disability and epilepsy. ASDs have a strong genetic basis as demonstrated by recurrence risk in families and twin studies. In recent years, genetic studies have identified several chromatin remodeling genes with causal roles in neurodevelopmental disorders

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