CNS Seminar – Xiao-Jing Wang, Ph.D.

Event Date

Location
Grey Hall, Conference Room 113
 
Talk title: Functional Specialization and distributed cognition in the neocortex 
Date and time: Friday, April 24th, 12:10 p.m.
Location: Grey Hall, Conference Room 113, 1544 Newton Court
 
Hosted by Rishi Chaudhuri, Ph.D., and Mark Goldman, Ph.D.
 
Abstract: With technological advances and availability of multi-omic data, studies of whole-brain circuits have come to the fore. Recent observations of widespread information coding have questioned functional modularity in the brain. We tackled this question using connectome-based large-scale modeling of cortex for monkeys and mice. I will highlight macroscopic gradients of synaptic excitation and inhibition as well as neuromodulation, as a general principle of the cortical organization which departs from the conventional idea of canonical local circuits. I will discuss findings ranging from a hierarchy of timescales to distributed working memory and decision-making. This line of work suggests that a new concept dubbed “bifurcation in space” can explain the emergence of functional modularity compatible with selectively distributed neural representations in the neocortex. 
 

 Hope to see you there!