Tony Simon

Tony Simon's picture
Professor

Ph.D.

(916) 703-0407
tjsimon@ucdavis.edu

Simon-vita.doc
Lab Webpage: 
http://www.ucdmc.ucdavis.edu/mindinstitute/research/cabil/

 

Dr. Simon is a pediatric cognitive neuroscientist. His research focuses on the neural basis of cognitive impairments seen in genetic disorders that produce developmental disability and psychopathology. Dr. Simon investigates how dysfunction in specific neurocognitive processing systems, such as spatial and temporal attention and cognition, can generate a range of cognitive and behavioral impairments. His goal is to develop remedial intervention programs that will minimize such disability. Dr. Simon's current projects center on studies of visuospatial and numerical cognition in children with chromosome 22q11.2 deletion syndrome, also known as DiGeorge and VeloCardioFacial syndrome. He is also engaged in similar studies of girls with Fragile Turner syndrome and also children and adults with the full range of fragile X (FMR1) gene mutations. This last project is part of the multidisciplinary NeuroTherapeutics Research Institute (http://www.ucdmc.ucdavis.edu/NTRI/), which involves numerous Neuroscience faculty, postdocs and graduate students. Besides cognitive processing analyses, Dr. Simon and his team use cutting edge neuroimaging methods, such as functional magnetic resonance imaging (fMRI), Voxel Based Morphometrics, and Diffusion Tensor Fiber Tracking in order to study the structure, function and connective patterns in the developing brain.

 

Selected Publications: 

 

Angkustsiri, K., Tartaglia, N.R., Leckliter, I., Enriquez, J., Hansen, R.L., Beaton, E.A., Simon, T.J. (2012) An examination of the relationship of anxiety and intelligence to adaptive functioning of children with chromosome 22q11.2 deletion syndrome. Journal of Development and Behavioral Pediatrics. 33, 713-720. DOI: 10.1097/DBP.0b013e318272dd24

Cabaral, M.H., Beaton, E.A., Stoddard, J.J., Simon, T.J. (2012) Impaired multiple object tracking in children with chromosome 22q11.2 deletion syndrome. Journal of Neurodevelopmental Disorders. 4:6, DOI:10.1186/1866-1955-4-6

Shapiro, H.M., Takarae, Y., Harvey, D., Cabaral, M., Simon, T.J. (2012) A Cross-sectional study of the development of volitional control of spatial attention in children with chromosome 22q11.2 deletion syndrome. Journal of Neurodevelopmental Disorders. 4:5, DOI: 10.1186/1866-1955-4-5

Stoddard, J., Takarae, Y., Simon, T.J. (2012) A second look: No effect of the COMT Val158Met single nucleotide polymorphism on adaptation to flanker interference in youth with chromosome 22q11.2 deletion syndrome. Schizophrenia Research.

Nordahl, C.W., Scholz, R., Yang, X., Buonocore, M., Simon, T.J., Rogers, S.J. Amaral, D.G. (2012) Increased rate of amygdala growth in 2-4 year olds with autism: a longitudinal study. Archives of General Psychiatry. 69, 53-61.

Srivastava, S., Buonocore, M., Simon, T.J. (2012) Atypical developmental trajectory of functionally significant cortical areas in children with chromosome 22q11.2 deletion syndrome. Human Brain Mapping, 33, 213-233. DOI: 10.1002/hbm.21206

Guo T, McDonald-McGinn D, Blonska A, Shanske A, Bassett AS, Chow E, Bowser M, Sheridan M, Beemer F, Devriendt K, Swillen A, Breckpot J, Digilio MC, Marino B, Dallapiccola B, Carpenter C, Zheng X, Johnson J, Chung J, Higgins AM, Philip N, Simon TJ, Coleman K, Heine-Suner D, Rosell J, Kates W, Devoto M, Goldmuntz E, Zackai E, Wang T, Shprintzen R, Emanuel B, Morrow B; International Chromosome 22q11.2 Consortium. (2011) Genotype and cardiovascular phenotype correlations with TBX1 in 1,022 velo-cardio-facial/DiGeorge/22q11.2 deletion syndrome patients. Hum Mutat. Nov;32(11):1278-89. doi: 10.1002/humu.21568.

Nordahl, C.W., Lange, N., Li, D., Barnett, L.A., Lee, A., Buonocore, M., Simon, T.J., Rogers, S.J., Ozonoff, S. Amaral, D.G. (2011) Brain enlargement is associated with regression in preschool age boys with autism. Proceedings of the National Academy of Sciences. 108, 20195-20200.

Simon, T.J. (2011) Clues to the Foundations of Numerical Cognitive Impairments: Evidence from Genetic Disorders. Developmental Neuropsychology, 36, 788-805. DOI:10.1080/87565641.2010.54987

Goodrich-Hunsaker. N.J., Wong, L., McLennan, Y., Tassone, F., Harvey, D., Rivera, S.M., Simon, T.J. (2011) Adult female fragile X premutation carriers exhibit age- and CGG repeat length-related impairments on an attentionally-based enumeration task. Frontiers in Human Neuroscience, 5, 63 DOI: 10.3389/fnhum.2011.00063

Goodrich-Hunsaker. N.J., Wong, L., McLennan, Y., Srivastava, S., Tassone, F., Harvey, D., Rivera, S.M., Simon, T.J. (2011) Enhanced manual and oral motor reaction time in young adult female fragile X premutation carriers. Journal of the International Neuropsychological Society, 17, 746-750.

Goodrich-Hunsaker. N.J., Wong, L., McLennan, Y., Srivastava, S., Tassone, F., Harvey, D., Rivera, S.M., Simon, T.J. (2011) Young adult female fragile X premutation carriers show age- and genetically-modulated cognitive impairments. Brain & Cognition, 75, 255-260.

Stoddard, J., Beckett, L., Simon, T.J. (2011) Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome. Journal of Neurodevelopmental Disorders. 3, 76-85.

Beaton, E.A. & Simon, T.J. (2011) How might stress contribute to increased risk for schizophrenia in children with chromosome 22q11.2 deletion syndrome? Journal of Neurodevelopmental Disorders. 3, 68-75.

Stoddard, J., Niendam, T., Hendren, R., Carter, C., Simon, T.J. (2010) Attenuated positive symptoms of psychosis in adolescents with chromosome 22q11.2 deletion syndrome. Schizophrenia Research, 118: 118-121

Karayiorgou, M., Simon, T.J., Gogos, J.A. (2010) 22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia. Nature Reviews Neuroscience. 11,  402-16

Beaton, E. A., Stoddard, J., Lai, S., Lackey, J., Shi, J., Ross, J.L., Simon, T.J. (2010). Atypical functional brain activation during a multiple object tracking task in girls with Turner syndrome: Neurocorrelates of reduced spatiotemporal resolution. American Journal on Inellectual and Developmental Disabilities 115, 2: 140-156

Takarae, Y., Schmidt, L., Tassone, F., Simon, T.J.(2009) Catechol-O-methyltransferase polymorphism modulates cognitive control in children with chromosome 22q11.2 deletion syndrome. Cognitive and Behavioral Neuroscience 9, 83-90. 

Simon, T.J., Wu, Z., Avants, B., Zhang, H., Gee, J.C., Stebbins, G.T. (2008) Atypical Cortical Connectivity and Visuospatial Cognitive Impairments are Related in Children with Chromosome 22q11.2 Deletion Syndrome. Behavioral and Brain Functions, 4: 25.

Simon, T.J. (2008) A New Account of the Neurocognitive Foundations of Impairments in Space, Time and Number Processing in Children with Chromosome 22q11.2 Deletion Syndrome. Developmental Disabilities Research Reviews. 14, 52-58.

Simon, T.J., Takarae, Y., DeBoer, T.L., McDonald-McGinn, D.M., Zackai, E.H., Ross, J.L. (2008) Overlapping Numerical Cognition Impairments In Children With Chromosome 22q11.2 Deletion Or Turner Syndromes. Neuropsychologia, 46, 82-94.

DeBoer, T., Wu, Z., Lee, A., Simon, T.J. (2007) Hippocampal Volume Reduction in Children with Chromosome 22q11.2 Deletion Syndrome is Associated with Cognitive Impairment. Behavioral and Brain Functions, 23: 54.

Machado, A.M.C., Simon, T.J., Nguyen, V., McDonald-McGinn, D.M., Zackai, E.H., Gee, J.C. Corpus callosum morphology and ventricular size in chromosome 22q11.2 deletion syndrome. (2007) Brain Research. 1131, 197-210.

Bish, J.P., Pendyal, A., Ding, L., Ferrante, H., Nguyen, V., McDonald-McGinn, D.M., Zackai, E.H., & Simon, T.J. (2006) Specific cerebellar reductions in children with chromosome 22q11.2 deletion syndrome. Neuroscience Letters. 399, 245-248.

Simon, T.J., Bearden, C.E., McDonald-McGinn, D., & Zackai, E. (2005) Visuospatial and numerical cognitive deficits in children with Chromosome 22q11.2 Deletion Syndrome. Cortex, 41: 131-141.

Simon, T.J., Ding, L., Bish, J.P., McDonald-McGinn, D., Zackai, E.H., & Gee, J. (2005) Volumetric, connective and morphologic changes in the brains of children with chromosome 22q11.2 deletion syndrome: An integrative study. NeuroImage, 25: 169-180.

Simon, T.J., Bish, J.P., Bearden, C.E., Ferrante, S., Ding, L., Nguyen, V., Gee, J., McDonald-McGinn, D., Zackai, E.H., & Emanuel, B. (2005) A multi-level analysis of cognitive dysfunction and psychopathology associated with chromosome 22q11.2 deletion syndrome in children. Development and Psychopathology. 17, 753-784.

Bish, J.P., Ferrante, S., McDonald-McGinn, D., Zackai, E.H., & Simon, T.J. (2005) Maladaptive conflict monitoring as evidence for executive dysfunction in children with chromosome 22q11.2 deletion syndrome. Developmental Science, 8: 36-43.

Bish, J.P., Nguyen, V., Ding, L., Ferrante, S., & Simon, T.J. (2004) Thalamic reductions in children with chromosome 22q11.2 deletion syndrome. NeuroReport, 15, 1413-1415.

Bish, J.P., Pendyal, A., Ding, L., Ferrante, H., Nguyen, V., McDonald-McGinn, D.M., Zackai, E.H., & Simon, T.J. (2006) Specific cerebellar reductions in children with chromosome 22q11.2 deletion syndrome. Neuroscience Letters. 399, 245-248.

Bearden, C.E., Jawad, A.F., Lynch, D.R., Sokol, S., Kanes, S.J., McDonald-McGinn, D., Saitta, S., Harris, S., Moss, E.M., Wang, P.P., Zackai, E., Emanuel, B.S., & Simon, T.J. (2004) Effects of function COMT polymorphism on prefrontal cognitive function in the 22q11.2 deletion syndrome. American Journal of Psychiatry, 161, 1700-1702.

Bearden, C.E., Jawad, A.F., Lynch, D.R., Monterosso, J.R., Sokol, S., McDonald-McGinn, D., Saitta, S., Harris, S., Moss, E.M., Wang, P.P., Zackai, E., Emanuel, B.S., & Simon, T.J. (2005) Effects of COMT genotype on behavioral symptomatology in the 22q11.2 deletion syndrome. Child Neuropsychology, 11(1), 109-117.

Other Affiliations: 

MIND Institute

Department of Psychiatry and Behavioral Sciences

Neuroscience

Center for Mind and Brain

Current Students: 
111 159 162
Postdocs and Research Personnel: 
Naomi Goodrich-Hunsaker

Current Students

Name Phone Email
Heather Shapiro hmshapiro@ucdavis.edu
Andrea Quintero aiquintero@ucdavis.edu
Ling Wong lmewong@ucdavis.edu

Postdocs and Research Personnel

Name Current Position Title Phone Email
Naomi Goodrich-Hunsaker