The research in this laboratory focuses on neurophysiological and genetic mechanisms in the CNS control of blood pressure and heart rate and how these mechanisms are altered during exercise, hypertension and heart failure. A related focus is on CNS control of breathing pattern and lung function, and how chronic exposure to environmental toxins, including allergens, passive cigarette smoke, and ozone induced neuroplasticity in the CNS region which affects breathing function. The laboratory utilizes electrophysiological approaches of single neuron recordings in vivo and whole-cell patch clamp recording in vitro, in addition to telemetry for monitoring blood pressure and heart rate in conscious freely moving mice, microinjection systems for making discrete injections of neuroactive agents in the CNS of conscious animals and real-time RT-PCR to measure changes in gene expression. Currently we are incorporating gene expression profiling to examine a wider array of genes that may be altered in the CNS during heart failure, hypertension and breathing abnormalities.

Teaching Interests:
Cardiovascular Pharmacology, second year medical students
Autonomic Neurosciences, Physiology Graduate Group
Neural control of cardiac function, Pharmacology and Toxicology graduate group

Publications:

2003 Sekizawa SI, Joad JP, Bonham AC. Substance P presynaptically depresses transmission of sensory input to bronchopulmonary neurons in nucleus tractus solitarius. J Physiol. Jul 18 (epub ahead of print)

2003 Chen, C-Y, AC Bonham, CG Plopper, JP Joad. Neuroplasticity in nucleus tractus solitarious neurons following episodic ozone exposure in infant primates, selected contribution article, Journal of Applied Physiology "Plasticity in Respiratory Motor Control" Highlighted Topics, J Appl Physiol. Feb;94(2):819-27

2002 Chen, C-Y, PA Munch, AW Quail, AC Bonham. Post-exercise hypertension in conscious SHR is attenuated by blockade of substance P receptors in nucleus tractus solitarius. Am J Physiol Heart Circ Physiol. Nov;283(5):H1856-62

2002 Chen C-Y, E Ling, JM Horowitz, AC Bonham. Synaptic transmission in nucleus tractus solitarius is depressed by Group II and III but not Group I presynaptic metabotropic glutamate receptors in rats. J Physiol 538 (3): 773-786.

2002 Kajekar R, C-Y Chen, T Mutoh, AC Bonham. GABAA receptor activation at medullary sympathetic neurons contributes to postexercise hypotension. Am J Physiol 282: H1615-H1624.

2002 Bonham AC, C-Y Chen. Glutamatergic neural transmission in the NTS: NMDA receptors. Clin Exp Pharmacol Physiol. 2002 May-Jun;29 (5-6):497-502

2002 Chen, C-Y, AC Bonham, CG Plopper, JP Joad. Neuroplasticity in nucleus tractus solitarious neurons following episodic ozone exposure in infant primates, selected contribution article, Journal of Applied Physiology "Plasticity in Respiratory Motor Control" Highlighted Topics, Feb 2003

2002 Chen, C-Y, PA Munch, AW Quail, AC Bonham. Post-exercise hypertension in conscious SHR is attenuated by blockade of substance P receptors in nucleus tractus solitarius. Am J Physiol Heart Circ Physiol. 2002 Nov;283(5):H1856-62

2001 Chen, C-Y, AC Bonham, LJ Gershwin, ES Schelegle, JP Joad: Extended allergen exposure induces neuroplasticity in the nucleus tractus solitarius (NTS) of Rhesus monkeys. J Allergy Clin Immunol 108 (4): 557-562.

2001 Bonham,AC, C-Y Chen , T Mutoh, JP Joad: Lung C-fiber CNS reflex: role in the respiratory consequences of extended environmental tobacco smoke exposure in young guinea pigs. Environ Health Perspect 109 (Suppl 4): 573-578.

2000 Mutoh, T., JP Joad and AC Bonham: Chronic passive cigarette smoke exposure augments brochopulmonary C-fibre inputs to nucleus tactus solitarius neurones and reflex output. J Physiol 523(1):223-233

2000 Mutoh, T., AC Bonham and JP Joad: Substance P int he nucleus tractus solitarius (NTS) augments bronchopulmonary C-fibre reflex output. AM J Physiol, 279(4):R1215-23

2000 Liu, Z., C-Y Chen, and AC Bonham. Frequency limits on aortic baroreceptor input to nucleus tractus solitarii. American Journal of Physiology, 278:H577-H585.

1999 Chen, C-Y, JM Horowitz, and AC Bonham: A presynaptic mechanism contributes to depression of autonomic signal transmission in NTS. Am. J. Physiol. 277(Heart Circ. Physiol.): H1350-H1360.

1999 Mutoh, T, AC Bonham, KS Kott and JP Joad: Chronic exposure to sidestream tobacco smoke augments lung C-fiber responsiveness in young guinea pigs. J. Appl. Physiol. 87 (2):757-768.

1998 Chen C-Y and AC Bonham: Non-NMDA and NMDA receptors transmit area postrema input to aortic baroreceptor neurons in nucleus tractus solitarius. Am. J. Physiol. 275 (Heart Circ. Physiol. 44): H1695-H1706.

1998 Liu Z, C-Y Chen and AC Bonham: Metabotropic glutamate receptors depress vagal and aortic baroreceptor signal transmission in the nucleus of the solitary tract. Am. J. Physiol. 275 (Heart Circ. Physiol. 44): H1682-H1694.

1998 Aylwin, ML, JM Horowitz and AC Bonham: Non-NMDA and NMDA receptors in the synaptic pathway between area postrema and nucleus tractus solitarius. Am. J. Physiol. 275 (Heart Circ. Physiol. 44): H1236-H1246.

1998 Joad JP, KS Kott and AC Bonham: Exposing guinea pigs to ozone for one week enhances responsiveness of rapidly adapting receptors. J. Appl. Physiol. 84 (4):1190-1197.

1997 Aylwin ML, JM Horowitz and AC Bonham: NMDA receptors contribute to primary visceral afferent transmission in the nucleus of the solitary tract. J. Neurophysiol. 77:2539-2548.

1997 Wilson CG and AC Bonham: Effect of cardiopulmonary C-fibre activation on the firing activity of ventral respiratory group neurones in the rat. J. Physiol. 504 (2): 453-466.

1997 Joad JP, KS Kott and AC Bonham: Nitric oxide contributes to substance P-induced increases in lung rapidly adapting receptor activity in guinea pigs. J. Physiol. 503 (3):635-643.

1997 Tjen-A-Looi S, AC Bonham and JC Longhurst: Interactions between sympathetic and vagal cardiac afferents in nucleus tractus solitarii. Am. J. Physiol. (41):H2843-H2851.

1997 Bonigut S, AC Bonham and CL Stebbins: Area postrema-induced inhibition of the exercise pressor reflex. Am. J. Physiol. 272 (Heart Circ. Physiol.) 41 H1650-H1655.

1996 Wilson CG, Z Zhang and AC Bonham: Non-NMDA receptors transmit cardiopulmonary C-fibre input in nucleus tractus solitarius (NTS) in rats. J. Physiol. 496(3):773-785.

1996 Bonham AC, KS Kott and JP Joad: Sidestream smoke exposure enhances rapidly adapting receptor responses to substance P in young guinea pig. J. Appl. Physiol. 81(4): 1715-1722.

1996 Bonham AC, KS Kott, K Ravi, CT Kappagoda and JP Joad: Substance P contributes to rapidly adapting receptor responses to pulmonary venous congestion in rabbits. J. Physiol. 493(1):229-238.

1995 Bonham AC , CT Kappagoda, KS Kott and JP Joad: Exposing young guinea pigs to sidestream tobacco smoke decreases rapidly adapting receptor responsiveness. J. Appl. Physiol. 78(4):1412-1420.

1995 Bonham AC, K Ravi, C Wilson, Z Zhang and CT Kappagoda: Pulmonary venous congestion augments respiratory motoneuronal responses to cigarette smoke in rabbit. J. Appl. Physiol. 78(3):1145-1157.

1995 Zhang Z and AC Bonham: Responses of neurones in the pulmonary rapidly adapting receptor afferent pathway to inhalation of cigarette smoke during pulmonary venous congestion in the rabbit. J. Physiol. 484(1):189-200.

1994 Pan H-L, AC Bonham, JC Longhurst: Role of spinal NK1 receptors in cardiovascular responses to chemical stimulation of the gallbladder. Am. J. Physiol. 268 (2 pt 2):H526-H534.

1994 Ravi K, CT Kappagoda and AC Bonham: Pulmonary congestion enhances responses of lung rapidly adapting receptors to cigarette smoke in rabbit. J. Appl. Physiol. 77(6):2633-2640.

1994 Ravi K, AC Bonham and CT Kappagoda: Effect of pulmonary lymphatic obstruction on respiratory rate and airway rapidly adapting receptor activity in rabbits. J. Physiol. 480(1): 163-170.

1994 Wilson CG and AC Bonham: Area postrema excites and inhibits sympathetic-related neurons in rostral ventrolateral medulla in rabbit. Am. J. Physiol.(3 pt 2):H1075-H1086.

1993 Bonham AC and EM Hasser: Area postrema and aortic or vagal afferents converge to excite cells in nucleus tractus solitarius. Am. J. Physiol. 264 (5 pt 2):H1674-H1685.

1993 Bonham AC, SK Coles and DR McCrimmon: Pulmonary stretch receptor afferents activate excitatory amino acid receptors in the nucleus tractus solitarii in rats. J. Physiol. 464:725-745.

1991 Bonham AC and JP Joad: Neurones in commissural nucleus tractus solitarii required for full expression of the pulmonary C-fibre reflex in rat. J. Physiol. 441:95-112.

1990 Arthur JM, AC Bonham, DD Gutterman, GF Gebhart, ML Marcus and MJ Brody: Coronary vasoconstriction during stimulation in the hypothalamic defense region. Am. J. Physiol. 260 (Reg. Int. Comp. Physiol. 29):R335-R345.

1990 Bonham AC and DR McCrimmon: Neurones in a discrete region of the nucleus tractus solitarius are required for the Breuer-Hering reflex in rat. J. Physiol. 427:261-280.

1990 Gutterman DD, AC Bonham, GF Gebhart, ML Marcus and MJ Brody: Connections between hypothalamus and medullary reticular formation mediate coronary vasoconstriction. Am. J. Physiol. 259 (Heart Circ. Physiol. 28): H917-H924.

1989 Gutterman DD, AC Bonham, JM Arthur, GF Gebhart, ML Marcus and MJ Brody: Characterization of coronary vasoconstrictor site in medullary reticular formation. Am. J. Physiol. 256 (Heart Circ. Physiol. 25):H1218-H1227.

1989 Bonham AC and I Jeske: Cardiorespiratory effects of DL-homocysteic acid in caudal ventrolateral medulla. Am. J. Physiol. 256 (Heart Circ. Physiol. 25):H688-H696.

1987 Bonham AC, DD Gutterman, JM Arthur, ML Marcus, GF Gebhart and MJ Brody: Neurogenic regulation of coronary blood flow: Evidence for a central nervous system pathway. Circ. Res. 61(Suppl. II):II-42 - II-46.

1987 Bonham AC, DD Gutterman, JM Arthur, ML Marcus, GF Gebhart and MJ Brody: Electrical stimulation in perifornical lateral hypothalamus decreases coronary blood flow in cats. Am. J. Physiol. 252 (Heart Circ. Physiol. 21):H474-H484.

1985 Porter JP, AC Bonham, ML Mangiapane, RL Webb and MJ Brody: The cardiovascular effects of centrally and peripherally administered indoramin in conscious rats. Eur. J. Pharmacol. 109:9-17.

1984 Faber JE, KW Barron, AC Bonham, R Lappe, EE Muirhead and MJ Brody: Regional hemodynamic effects of antihypertensive renomedullary lipids in conscious rats. Hypertension 6 (4):494-502.

1984 Brody MJ, RL Webb, ML Mangiapane, JP Porter, AC Bonham and AJ Trapani: Comparative central and peripheral antihypertensive mechanisms of urapidil and prazosin. Am. J. Med. 77 (4A): 74-80.

1984 Bonham AC, AJ Trapani, LR Portis and MJ Brody: Studies on the mechanism of the central antihypertensive effect of guanabenz and clonidine. J. Hypertension 2 (suppl. 2): 543-546.

1984 Ahrens RC, AC Bonham, GA Maxwell and MM Weinberger: A method for comparing the peak intensity and duration of action of aerosolized bronchodilators using bronchoprovocation with methacholine. Am. Rev. Resp. Dis. 129:903-906.

1984 Autor AP, AC Bonham and RL Thies: Toxicity of oxygen radicals in cultured pulmonary endothelial cells. J. Toxicol. Environ. Health 13:387-395.

1980 Bonham AC, L Hendeles, L Vaughn and M Weinberger: The reliability of serum theophylline determinations from clinical laboratories. Am. Rev. Resp. Dis.122:829-832.