Our main research goal is to understand the relationsip between brain structure and brain function in aging and disease. Specifically, the lab investigates populations of individuals to assess brain changes associated wtih age, cerebrovascular disease, and Alzheimer's Disease. Additional projects include the study of heritability of brain regions and abnormal white matter signals.

Publications:

DeCarli, C; Miller, BL; Swan, GE; Reed, T; Wolf, PA; Carmelli, D. Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin Study. Archives of Neurology 2001 Apr, 58(4):643-7.

Reed T, Kirkwood SC, DeCarli C, Swan GE, Miller BL, Wolf PA, Jack LM, Carmelli D. Relationship of family history scores and hypertension to quantitative measures of white matter hyperintensities and stroke volume in elderly males. Neuroepidemiology

Carmelli D, DeCarli C, Swan GE, Kelly-Hayes M, Wolf PA, Reed T, Guralnik JM. The mediating effect of apolipoprotein E4 in the association of MRI findings with cognitive decline and lower extremity function. J Gerontol A Biol Sci Med Sci 55: M103

Geroldi C, Laakso, MP, DeCarli C, Beltramello A, Bianchetti A, Soininen H, Trabuchhi M, Frisoni GB. Apolipoprotein E genotype and hippocampal asymmetry in Alzheimer's disease: A volumetric MRI study. Journal of Neurology, Neurosurgery & Psychiatry

Guo, Z, Gupples LA, Kurz A, Auerbach S, Volicer L, Chui H, Green RC, Sadovnic AD, Duara R, DeCarli C, Johnson K, Go, RC, Growdon JH, Haines JL, Kukull WA, Farrer LA. Head injury and the risk of Alzheimer disease in the MIRAGE study. Neurology 54: