Proteomic analysis of cell signaling in mammalian neurons, neuronal cell biology, membrane protein trafficking and function

Courses Taught:
NSC 221 Cellular Neuroscience - Term(s): Fall

NPB107 Cell Signaling in Health and Disease - Term(s): Winter

Publications:

Seikel, E. and J. S. Trimmer. (2009). Convergent Modulation of Kv4.2 Channel Alpha Subunits by Structurally Distinct DPPX and KChIP Auxiliary Subunits. Biochemistry 48:5721-5730.

Mikula, S., Parrish, S. K., Trimmer, J. S., and E. G. Jones. (2009). Complete 3D Visualization of Primate Striosomes by KChIP1 Immunostaining. J. Comp. Neurol. 514: 507-517.

Vacher, H., and J. S. Trimmer. (2009). Shaker Family Kv1 Voltage-gated Potassium Channels in Mammalian Brain Neurons. (Chapter 5, pp. 127-154). In Structure, Function and Modulation of Neuronal Voltage Gated Ion Channels. (V. Gribkoff and L. K. Kaczmarek, eds.). John Wiley and Sons, Hoboken.

Rasband, M. N., and J. S. Trimmer. (2008). Ion Channel Localization in Axons. (pp. 229-235). In Encyclopedia of Neuroscience. (L. R. Squire, ed.). Elsevier Academic Press, London.

Yan, J., Olsen, J. V., Park, K.-S., Li, W., Bildl, W., Schulte, U., Aldrich, R. W., Fakler, B., and J. S. Trimmer. (2008). Profiling the Phospho-status of the BKCa Channel Alpha Subunit in Rat Brain Reveals Unexpected Patterns and Complexity. Mol. Cell. Proteomics 7:2188-2198.

Martinez, H. D., Jasavala, R. J., Hinkson, I., Fitzgerald, L., Trimmer, J. S., Kung, H.-J., and M. E. Wright. (2008). RNA Editing of Androgen Receptor Gene-Transcripts in Prostate Cancer Cells. J. Biol. Chem. 283:29938-29949.

Vacher, H., Mohapatra, D. P., and J. S. Trimmer. (2008). Localization and Targeting of Voltage-Gated Ion Channels in Mammalian Central Neurons. Physiol. Rev. 88:1407-1447.

Monaghan, M. M., Menegola, M., Vacher, H., Rhodes, K. J., and J. S. Trimmer. (2008). Altered Expression and Localization of Hippocampal A-Type Potassium Channel Subunits in the Pilocarpine-Induced Model of Temporal Lobe Epilepsy. Neurosci. 156:550-562.

Menegola, M., Misonou, H., Vacher, H., and J. S. Trimmer. (2008). Dendritic A-type Potassium Channel Subunit Expression in CA1 Hippocampal Interneurons. Neurosci. 154:953-964.

Ogawa, Y., Horresh, I., Trimmer, J. S., Bredt, D. S., Peles, E., and M. N. Rasband. (2008). PSD-93 Clusters Kv1 Channels at Axon Initial Segments Independent of Caspr2. J. Neurosci. 28: 5731-5739.

Mohapatra, D. P., Siino, D. F., and J. S. Trimmer. (2008). Interdomain Cytoplasmic Interactions Govern the Intracellular Trafficking, Gating and Modulation of the Kv2.1 Channel. J. Neurosci. 28: 4982-4994.

Rhodes, K. J., and J. S. Trimmer. (2008). Antibody-based Validation of CNS Ion Channel Drug Targets. J. Gen. Physiol. 131:407-413.

Park, K.-S., Yang, J.-W., Seikel, E., and J. S. Trimmer. (2008). Potassium Channel Phosphorylation in Excitable Cells: Providing Dynamic Functional Variability to a Diverse Family of Ion Channels. Physiology 23:49-57.

Yang, J.-W., Vacher, H., Park, K.-S., Clark, E, and J. S. Trimmer. (2007). Trafficking-dependent Phosphorylation of Kv1.2 Regulates Voltage-gated Potassium Channel Cell Surface Expression. Proc. Nat. Acad. Sci. USA 104: 20055-20060.

Mohapatra, D. P., Park, K.-S., and J. S. Trimmer. (2007). Dynamic Regulation of the Voltage-gated Kv2.1 Potassium Channel by Multi-Site Phosphorylation. Biochem. Soc. Trans. 35: 1064-1068.

Wenzel, H. J, Vacher, H., Clark, E., Trimmer, J. S., Lee, A. J., Sapolsky, R. M., Tempel, B. L., and P. A. Schwartzkroin. (2007). Structural Consequences of KCNA1 Gene Deletion and Transfer in the Mouse Hippocampus. Epilepsia 48:2023-2046.

Park, K.-S., Mohapatra, D. P., and J. S. Trimmer. (2007). Proteomic Analyses of Kv2.1 Channel Phosphorylation Sites Determining Cell Background-Specific Differences in Function. Channels 1: 59-61

Mohapatra, D. P., Vacher, H., and J. S. Trimmer. (2007). The Surprising Catch of a Voltage-Gated Potassium Channel in a Neuronal SNARE. Sci STKE. 2007(393):pe37.

Rasmussen, H. B., Frokjaer-Jensen, C., Jensen, C. S., Jensen, H. S., Jorgensen, N. K., Misonou, H., Trimmer, J. S., Olesen, S.-P., and N. Schmitt. (2007). Requirement of Subunit Co-Assembly and Ankyrin-G for M Channel Localization at the Axon Initial Segment. J. Cell Sci. 120:953-963.

Vacher, H., Mohapatra, D. P., Misonou, H., and J. S. Trimmer. (2007). Regulation of Kv1 Channel Trafficking by the Mamba Snake Neurotoxin Dendrotoxin K. FASEB J. 21:906-914.

Van Wart, A., Trimmer, J. S., and G. Matthews. (2007). Polarized Distribution of Ion Channels Within Microdomains of the Axon Initial Segment. J. Comp. Neurol. 500:339-352.

Misonou, H., Menegola, M., Mohapatra, D. P., Guy, L. K., Park, K.-S., and J. S. Trimmer. (2006). Bidirectional Activity-Dependent Regulation of Neuronal Ion Channel Phosphorylation. J. Neurosci. 26:13505-13514.

Menegola, M., and J. S. Trimmer. (2006). Unanticipated Region- and Cell-specific Downregulation of Individual KChIP Auxiliary Subunit Isotypes in Kv4.2 Knockout Mouse Brain. J. Neurosci. 26:12137-12142.

Clark E. Vacher H, and J. S. Trimmer. (2006). Kv1.1 takes a deTOR from the Axon to the Dendrite. Neuron 52:399-401.

Vacher, H., Misonou, H., and J. S. Trimmer. (2006). Determinants of Voltage-Gated Potassium Channel Distribution in Mammalian Neurons. (Chapter 12, pp. 244-270. In Protein Trafficking in Neurons (A. J. Bean, ed) Elsevier Academic Press, London.

Park, K.-S., Mohapatra, D. P., Misonou, H., and J. S. Trimmer. (2006). Graded Regulation of the Kv2.1 Potassium Channel by Variable Phosphorylation. Science 313:976-979.

Rhodes, K. J., and J. S. Trimmer. (2006). Antibodies as Valuable Neuroscience Research Tools versus Reagents of Mass Distraction. J. Neurosci. 26:8017-8020.

Rasband, M. N., and J. S. Trimmer. (2006). Voltage-gated Potassium Channels in Sensory Neurons (Chapter 11, pp. 323-352). In The Nociceptive Membrane (U. Oh, ed.) Academic Press, San Diego.

Misonou, H., Menegola, M., Buchwalder, L., Park, E. W., Meredith, A., Rhodes, K. J., Aldrich, R. W., and J. S. Trimmer. (2006). Immunolocalization of the Ca2+-activated K+ Channel Slo1 in Axons and Nerve Terminals of Mammalian Brain and Cultured Neurons. J. Comp. Neurol. 496:289-302.

Mohapatra, D. P., and J. S. Trimmer. (2006). The Kv2.1 C-Terminus Can Autonomously Transfer Kv2.1-Like Phosphorylation-Dependent Localization, Voltage-Dependent Gating and Muscarinic Modulation to Diverse Kv Channels. J. Neurosci. 26:685-695.