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W. Martin Usrey
The long-term goal of the Usrey laboratory is to understand the functional properties of neural circuits that serve vision and the relationship between circuit activity, behavior and perception. Current research projects are focused on determining (1) how sensory information is processed and transmitted within and between brain areas, (2) the cellular and circuit mechanisms that mediate the effects of spatial attention on visual processing, (3) the role of feedback pathways for vision, (4) the relationship between neural activity and visual perception, and (5) the molecular, cellular, and circuit mechanisms that establish parallel processing streams in the prenatal retina. Using an arsenal of techniques that includes whole-cell and multielectrode recordings from the isolated retina along with molecular phenotyping of identified cells, single and multielectrode recordings from anesthetized and behaving animals, optogenetic manipulation of neuronal activity, and fMRI, we are discovering how sensory information is established and encoded in brain activity, as well as the mechanisms employed by the brain for communicating information dynamically from one level to the next. The Usrey laboratory is also home to Brainmaps.org, an interactive, high-resolution digital brain atlas and virtual microscope for students, educators, and researchers.
Our research is funded by the NIH, the NSF, the McKnight Foundation, the Esther A. and Joseph Klingenstein Foundation, and the Alfred P. Sloan Foundation.
Teaching Interests: Systems Neuroscience, Neurobiology of Vision, Neuroanatomy, Human Physiology. Courses Taught: NSC 201 Neuroanatomy - Term(s): Fall NSC 222 Systems Neuroscience - Term(s): Winter NPB 101 Human Physiology - Term(s): Winter NSC 261B Visual Neuroscience - Term(s): Winter
(Selected from 55 publications)
Briggs F, Mangun GR, and Usrey WM. (2013) Attention Enhances Synaptic Efficacy and Signal-to-Noise in Neural Circuits. Nature 499:476-480.
Bastos AM, Usrey WM, Adams RA, Mangun GR, Fires P, and Friston KJ. (2012) Cononical microcircuits for predictive coding. Neuron 76:695-711.
Reid RC, and Usrey WM. (2012) Vision. In: Fundamental Neuroscience, 4th Edition. Eds, Squire LR, Roberts JL, Spitzer NC, Zigmond MJ, McConnell SK, Bloom FE. Academic Press. San Diego.
Moore BD, Kiley CW, Sun C, and Usrey WM. (2011) Rapid plasticity of visual responses in the adult lateral geniculate nucleus. Neuron 71:812-819.
Briggs F, and Usrey WM. (2011) Distinct mechanisms for size tuning in primate visual cortex. Journal of Neuroscience 31:12644-12649.
Lankow BS, and Usrey WM. (2011) Visual processing in the monkey. In: Monkeys: Biology, Behavior and Disorders. RM Williams (Ed). pp 181-197.Nova Science Publishers, Inc.
Briggs F, and Usrey WM. (2011) Corticogeniculate feedback and parallel processing in the primate visual system. Journal of Physiology 589:33-40.
Alitto HJ, Moore BD, Rathbun DL, and Usrey WM. (2011) A comparison of visual responses in the lateral geniculate nucleus of alert and anesthetized macaque monkeys. Journal of Physiology 589:87-99.
Rathbun DL, Warland DK, and Usrey WM. (2010) Spike timing and information transmission at retinogeniculate synapses. Journal of Neuroscience 30:13558-13566
Briggs F, and Usrey WM. (2009) Parallel processing in the corticogeniculate pathay. Neuron 62:135-146.
Center for Neuroscience Neuroscience
Postdocs and Research Personnel
|Katie Neverkovec, Deborah van der List, Jim Stone, Dan Sperka, Jeff Johnson|
|Andre Bastos (PhD 2013), Postdoc at MIT|
|Bart Moore (PhD 2010), Postdoc at UT Houston|
|Daniel Rathbun (PhD 2009), Postdoc at University of Tubingen|
|Corey Ziemba (BS 2008), Graduate Student New York University|
|Henry Alitto (PhD 2007), Research Scientist, UC Davis|
|Michael Sceniak, PhD (Postdoc 2002), Case Western University|
|Katie Neverkovec||Lab Manager||(530)firstname.lastname@example.org|
|Dan Sperka||Computer Specialist||(530)email@example.com|