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Campus/Davis InformationUC Davis Research and Training ResourcesAlzheimer's Disease Research CenterThe University of California, Davis Alzheimer's Disease Center (UCD ADC) conducts many different kinds of research studies. Many involve trying to describe and understand the behavioral and mental changes which occur with dementing illness. Some studies involve potential new treatments, or ways of preventing mental loss. Other studies involve genetics or studies of basic biologic processes related to Alzheimer's disease. Under the direction of Professor and Chair W Jagust MD, the NIH-funded Alzheimer's Disease Center (ADC) provides a fully-staffed site for the care and etiologic studies of up to 250 new dementia patients per year, 90% of whom carry the diagnosis of Alzheimer's Disease. An electronic base of clinical, cognitive, and imaging characteristics and of DNA samples is maintained on over 500 live patients with a complementary brain bank. The Alzheimer's Disease Research Center is funded by the State of California through the Department of Health Services (DHS) and by the NIH, National Institute on Aging (NIA). UC Davis has clinical centers in Sacramento and Martinez. More information here. Animal Resources Service The Animal Resources Service (ARS) provides for the care and well-being of more than 14,000 small to large animals used for teaching and research by UC Davis faculty. ARS is a department of the School of Veterinary Medicine that serves all UC Davis faculty. In addition to housing in individual cages and pens, the ARS provides veterinary services and surgical and necropsy suites. The ARS is a fully accredited AALAC facility. Through a funding arrangement with the CAES, the ARS also provides veterinary services at no direct cost to investigators using Core animal facilities. Becton Dickinson Immunocytometry Systems Flow Cytometry Laboratory and Training Facility This facility houses a FACS Calibur flow cytometry system, used to measure light scatter and fluorescence of single cells or particles. It measures four fluors simultaneously, three from 488 nm excitation and one from 633 nm excitation. The system also has a mechanical sorter. The facility provides flow cytometry training for undergraduates, graduate students, faculty members, and staff members from throughout the campus. Location: Life Sciences Addition, Room 1110 Contact: Donna Lagarias, facility director, Section of Molecular and Cellular Biology; (530) 754-9441, dmlagarias@ucdavis.edu Biotechnology Program To assist in the organization of University activities related to biotechnology and to coordinate such activities with other efforts on the Davis campus, a Biotechnology Program was created. The Program's missions include: (1) Promoting and coordinating the development of biotechnology and biotechnology-related research on the campus; (2) Assisting with development of new and improved facilities for biotechnology research; (3) Promoting research interactions between faculty and private industry and public agencies; (4) Recommending and implementing curriculum development and training in biotechnology; (5) Serving as an information and education resource on biotechnology for the campus and the public. California Regional Primate Center The California Regional Primate Center is a research resource for investigators working with non-human primates. Research at the center includes behavioral and neurobiology, developmental and reproductive biology, pulmonary function and respiratory diseases, virology and immunology, and genetics. Center for Genetics and Development Designed to establish the campus as an international leader in functional and comparative genomics, the UC Davis Genome Center will include scientists specializing in gene studies from a multitude of disciplines, including human and animal medicine, engineering, agriculture, and the biological and physical sciences. The Center will be housed in a 200,000 sqft building, called the Genome and Biomedical Sciences Building, currently being constructed near the Medical school on the UC Davis campus. Center for Imaging Processing and Integrated Computing The Center for Imaging Processing and Integrated Computing is an interdisciplinary research center with strengths in imaging, computer science, and engineering. Of special interest to the center is three-dimensional modeling, imaging, and visual communication. Other areas of research are the access and use of large pictorial data bases and network-based data sharing. Center for Neuroscience The UC Davis Center for Neuroscience is the home-base for the Neuroscience Graduate Group. The Center draws from a wide variety of resources to conduct its teaching and research programs. Contributing to this interdisciplinary approach are Center faculty members, postdocs, students, and collaborators who represent 13 academic departments and sections on the main campus and a number of off-campus sites. These sites include the UC Davis Medical Center in Sacramento, the Veterans Administration Health Care System Outpatient Clinic in Martinez, other hospitals in northern California, and other universities worldwide. In addition, visiting faculty members from throughout the world bring outstanding talent to the Center's programs. Research at the Center ranges from single-cell recordings and studies of neuronal populations in isolation to studies of human perception, attention, memory, language, and the nature of consciousness. The Center places special emphasis on combining information obtained from different brain-imaging techniques, including fMRI, PET, and ERPs, to develop improved methods to treat brain injury and disease. CBS Sequencing College of Biological Sciences (CBS) Automated DNA Sequencing Facility is committed to providing quality sequences to research facilities across all UC campuses of California. Turn-around time is 2 days. Facility for Advanced Instrumentation The Facility for Advanced Instrumentation supports teaching and research programs in electron microscopy, related microimaging techniques, and mass spectroscopy. The electron microscope laboratory has several scanning and transmission electron microscopes with x-ray detectors and a well-equipped specimen preparation laboratory. An atomic force microscope and an FTIR-microscope complement these capabilities. The mass spectrometer facility is composed of 5 mass spectrometers including GC/MS, LC/MS and high resolution instruments, and offers MALDI and electrospray ionization capabilities. Analyses can be performed on substances as large as proteins, oligosaccharides, and nuclei acids. Students from all departments are encouraged to learn how to use facility instruments to support their research. Human Brain Project A recent application has been submitted for Human Brain Project funding. The project is built around and designed to manage data obtained from high resolution human and monkey brain atlases, molecular and cellular mapping studies, morphometry and physiology of retinal and thalamic cells, and studies of brain connections. The goals of this projects are four-fold: (1) To develop a Neuroscience Information System that contains a Neuroscience Information Repository (NIR) with tools for thesaurus and metadata creation and database manipulation to permit indexing, linking and retrieval of graphical and non-graphical datasets, using the primate lateral geniculate nucleus as a model. (2) To develop a NeuroImage Repository with visualization technology that can manipulate, simplify and graphically display 2-D and 3-D representations of high resolution cytoarchitectonic and single neuron images that form parts of large image datasets of monkey brain, of human thalamus or vertebrate retina. (3) To develop tools for manipulation and display of high resolution digital histological atlases of macaque and human brains, for overlaying and extracting image-oriented data derived from studies of gene expression in normal and pathological brains, and for constructing Neuroscience-specific thesauri (vocabularies) that use NIR to cross reference among graphical and non-graphical datasets, using the lateral geniculate nucleus as a model. (4) To develop tools for creating and extending databases of Neuroscience information based on image, physiological or connectional data, for building new comparative databases and thesauri of cell typology, morphometry or connections, and for making links between these and other databases. Institute of Theoretical Dynamics The Institute of Theoretical Dynamics promotes research and graduate education in the mathematical sciences, focusing on 3 major areas of emphasis: mathematical physics, mathematical biology, and applied mathematical analysis. At present, approximately 30 faculty from all of the colleges participate in the activities of the Institute. Particularly relevant to neuroscience, members of the Institute are integrally involved in the medical informatics component of the human brain project. The Institute houses the NSF Computer Graphics Facility for Computational Biology, which is open to faculty, graduate students, and postdoctoral researchers for graphic visualization in biology. The Institute is also the center for an NSF Biology Research Training group, "Nonlinear Dynamics in Biology." This interdisciplinary training program involves 22 faculty trainers carrying out research on dynamical problems in cell and neurobiology, and ecology and population biology. Microscopy and Imaging Facility, College of Biological Sciences Among the imaging instruments housed by this facility is a Philips 410LS transmission electron microscope with a Gatan CCD camera for digital image capture and a Hitachi S3500-N scanning electron microscope with variable pressure chamber, cold stage and cryo stage. Also available are a Leica Ultracut-T ultramicrotome, sputter coater, vacuum evaporator, and critical point dryer. The facility also has two inverted laser scanning confocal microscopes, a Leica TCS-SP and a Zeiss LSM410. Image-processing computer hardware and software are also available and a dye-sub printer and poster printer. UC Davis faculty members, students, and staff may receive training and use the equipment on a fee-for-service basis. Transmission Electron Microscope Scanning Electron Microscope Location: Life Sciences Addition, Room 1241A Confocal Microscopes Location: Life Sciences Addition, Room 3144 (Leica TCS-NT) and Room 3105 (Zeiss LSM410) Facility Information and Online scheduling: http://katie.ucdavis.edu/ Contact for Facility and Electron Microscopes: Rick Harris, facility director, (530) 752-2914, raharris@ucdavis.edu Contact for Laser Confocal Microscopes: Ray Fontanilla, (530) 752-7253, rafontanilla@ucdavis.edu General Information: Ronald Baskin, imaging committee chair, (530) 752-1554, rjbaskin@ucdavis.edu M.I.N.D. Institute The University of California, Davis, Health System has established a unique interdisciplinary institute to conduct research and provide clinical programs focused on these disorders. The M.I.N.D. Institute is rapidly becoming a national resource for the study and treatment of neurodevelopmental disorders. Leading scientists, physicians and educators in fields as diverse as molecular genetics and clinical pediatrics are joining forces to better understand development and brain function. The Institute focuses on neurodevelopmental disorders in children and adults, including autism and autism spectrum disorders, Fragile X syndrome, mental retardation, and other learning, developmental delay, and communication disorders. Monoclonal Antibody Laboratory Service and expertise in hybridoma technology is provided by researchers at the Monoclonal Antibody Laboratory. The laboratory staff assist interested faculty members in the development of monoclonal antibodies against a specific antigen by performing fusions and screening hybridomas to identify and produce the desired antibodies. Neuroscience Informatics Group Northern California Positron Emission Tomography Imaging Center (NCPIC) The Northern California Positron Emission Tomography Imaging Center (NCPIC) in Sacramento is a clinical facility for brain, cardiac, and whole-body imaging using short-lived positron emitter-labeled radiopharmaceuticals and the tomogr aphic imaging system. A collaborative research program between the Center for Neuroscience and NCPIC has placed duplicate computer systems in the two centers to ensure consistency among patient studies of brain electrical activity at the Center for Neuroscience and PET studies at NCPIC. Nuclear Magnetic Resonance Facility The Nuclear Magnetic Resonance Facility provides researchers access to state-of-the-art instrumentation for spectroscopy and imaging. The facility operates 6 spectrometers of varying purposes and capabilities. Three horizontal magnet bore spectrometers are utilized for in vivo spectroscopy and imaging of materials and small animals, and in vitro spectroscopy of perfused organs. Three vertical bore spectrometers are used primarily for solution study of biomolecules. The staff provides training and consultation. Protein Structure Laboratory The Protein Structure Laboratory provides protein sequencing, amino acid analysis, and peptide and DNA synthesis for investigators from throughout the campus as well as for other institutions and some companies. The laboratory also provides consultation and expertise on the application of these techniques and has many protocols and reagents available to assist investigators. Transgenic Mouse Facility/ Murine Targeted Genomics Laboratory The Murine Targeted Genomics Laboratory is a core laboratory for the UC Davis Mouse Biology Program which encompasses a campus-wide initiative among the Schools of Medicine, Veterinary Medicine, and the College of Biological Sciences designed to support advanced research and training in mouse biology. The goals of the Laboratory are twofold: first, to be a leader in the development and application of modern techniques in molecular manipulation of the mouse genome to address basic and applied research interests as varied as neural development of the hindbrain to the creation of models of human and animal disease; and, second, to train a new generation of basic science researchers and professional academicians in the emerging and expanding field of mouse biology with an emphasis on the genetically-altered mouse. The Rowe Program in Genetics The Rowe Program in Human Genetics is a multidisciplinary program in the School of Medicine designed to facilitate studies of human and mammalian genetics. Housed in offices and laboratories in Tupper Hall on the Davis campus and directed by CNRU investigator Michael F. Seldin MD, PhD, this program supports five faculty members whose research foci include the use of human and mouse models of immune disease, the use of knock-out technology in mice to study genes of cartilage synthesis, molecular mechanisms of chromosomal imprinting, statistical genetics, and the genetic basis of obesity, the last conducted by CNRU investigator and Genetics & Animal Models Core Director Craig H. Warden, PhD. W.M. Keck Center for Structural Biology X-ray Crystallography Suite This facility currently houses two rotating anode X-ray generators with two area detectors. One area detector is an image plate named "Raxis-IV." The other area detector is a "Siemens Hi-Star Multiwire." Location: Chemistry Annex, Room 4445 Contact: Andrew Fisher, assistant professor, Department of Chemistry, (530) 754-6180, fisher@chem.ucdavis.edu Protein Expression Facility This facility enables UC Davis scientists and students to use bacteria, yeast, and cell culture systems to produce large quantities of protein necessary for X-ray crystallography studies. Location: Briggs Hall, Rooms 8 and 16 Contacts: David Wilson, assistant professor, Section of Molecular and Cellular Biology, (530) 752-1136, dkwilson@ucdavis.edu; Enoch Baldwin, assistant professor, Section of Molecular and Cellular Biology, (530) 752-1108, epbaldwin@ucdavis.edu; or Andrew Fisher, assistant professor, Department of Chemistry, (530) 754-6180, fisher@chem.ucdavis.edu Back to campus info |
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