James Trimmer, Ph.D.

 James  Trimmer, Ph.D.

Position

  • Professor
  • Neurobiology, Physiology and Behavior (Physiology and Membrane Biology)

Cell Signaling in Mammalian Neurons, Neuronal Cell Biology, Membrane Protein Trafficking and Function

Research Summary

Proteomic analysis of cell signaling in mammalian neurons, neuronal cell biology, membrane protein trafficking and function.

Select Publications

Gong, B., Murray, K. D., and J. S. Trimmer. Developing High-Quality Mouse Monoclonal Antibodies for Neuroscience Research – Approaches, Perspectives and Opportunities. New Biotech. (in press).

Cobb, M. M., Austin, D. C., Sack, J. T., and J. S. Trimmer. (2015). Cell Cycle-Dependent Changes in Localization and Phosphorylation of the Plasma Membrane Kv2.1 K+ Channel Impact Endoplasmic Reticulum Membrane Contact Sites in COS-1 Cells. J. Biol. Chem. 290:29189-29201.

Bishop, H. I., Guan, D., Bocksteins, E., Parajuli, L., Murray, K. D., Cobb, M. M., Misonou, H., Zito, K., Foehring, R. C., and J. S. Trimmer. (2015). Distinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal Neurons. J. Neurosci. 35:14922-14942.

Thiffault, I., Speca, D. J., Austin, D. C., Cobb, M. M., Eum, K. S., Safina, N. P., Grote, L., Farrow, E. G., Miller, N., Soden, S., Kingsmore, S. F., Trimmer, J. S., Saunders, C. J., and J. T. Sack. (2015) A Novel Epileptic Encephalopathy Mutation in KCNB1 Disrupts Kv2.1 Ion Selectivity, Expression, and Localization.J. Gen. Physiol. 146:399-410.

Cerda, O., Leiva-Salcedo, E., Park, K.-S., Cáceres, M., Romeroa, A., Varela, D., Trimmer, J. S., and A. Stutzinband. (2015). Casein Kinase-Mediated Phosphorylation of Serine 839 Is Necessary for Basolateral Localization of the Ca2+-Activated Non-Selective Cation Channel TRPM4. Pflugers Arch. 467: 1723-1732.

Jan, L. Y., Attali, B., Nerbonne, J., Sanguinetti, M. C., Trimmer, J. S.,  Chandy, K. G., Grissmer, S., Gutman, G. A., Lazdunski, M., Mckinnon, D., Pardo, L. A., Robertson, G. A., Rudy, B., Stühmer, W., and X. Wang. Voltage-Gated Potassium Channels. IUPHAR/BPS Guide to PHARMACOLOGY,  http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=81.

Cáceres, M., Ortiz, L., Romero, A., Recabarren, T., Colombo, A., Leiva-Salcedo, E., Varela, D., Rivas, J., Silva, I., Campusano, C., Almarza, O., Simón, F., Toledo, H., Park, K.-S., Trimmer, J. S., and O. Cerda. (2015). TRPM4 is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility. PLoS ONE 10:e0130540.

Hirono, M., Ogawa, Y., Misono, K., Zollinger, D. R., Trimmer, J. S., Rasband, M. N., and H. Misonou. (2015). BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells. J. Neurosci. 35:7082-7094.

Trimmer, J. S., and H. Misonou. (2015). Ion Channel Phosphorylation. (Chapter 36, pages 531-544). InThe Handbook of Ion Channels. (J. Zheng and M. C. Trudeau, Editors). CRC Press, Boca Raton, FL.

Hsiao, J. J., Ng, B. H., Smits, M. M., Wang, J., Jasavala, R. J., Martinez, H. D., Lee, J. A., Alston, J. J., Misonou, H., Trimmer, J. S., and M. E. Wright. (2015). Androgen Receptor and Chemokine Receptors 4 and 7 Form a Signaling Axis to Regulate CXCL12-Dependent Cellular Motility. BMC Cancer 15:204.

 Trimmer, J. S. (2015). Subcellular Localization of K+ Channels in Mammalian Brain Neurons: Remarkable Precision in the Midst of Extraordinary Complexity. Neuron 85: 238-256.

Mandikian, D., Bocksteins, E., Parajuli, L., Bishop, H. I., Cerda, O., Shigemoto, R., and J. S. Trimmer. (2014). Cell Type Specific Spatial and Functional Coupling Between Mammalian Brain Kv2.1 K+ Channels and Ryanodine Receptors. J. Comp. Neurol. 522:3555-3574.

King, A. N., Manning, C. F., and J. S. Trimmer. (2014). A Unique Ion Channel Clustering Domain on the Axon Initial Segment of Mammalian Neurons. J. Comp. Neurol. 522: 2594-2608.

Baek, J.-H., Rubinstein, M., Scheuer, T., and J. S. Trimmer. (2014). Reciprocal Changes in Phosphorylation and Methylation of Mammalian Brain Sodium Channels in Response to Seizures. J. Biol. Chem. 289: 15363-15373.

Speca, D. J., Ogata, G., Mandikian, D., Bishop, H. I., Wiler, S. W., Eum, K., Wenzel, H. J., Doisy, E. T., Matt, L., Campi, K. L., Golub, M. S., Nerbonne, J. M., Hell, J. W., Trainor, B., Sack, J. T., Schwartzkroin P. A., and J. S. Trimmer. (2014). Deletion of the Kv2.1 Delayed Rectifier Potassium Channel Leads to Neuronal and Behavioral Hyperexcitability. Genes Brain Behav. 13: 394-408.

Trimmer, J. S. (2014). Ion Channels and Pain: Important Steps Towards Validating a New Therapeutic Target for Neuropathic Pain. Exp. Neurol. 254: 190-194.

Affiliations

Professor-in-Residence, Department of Physiology and Membrane Biology, School of Medicine

Director, UC Davis/NIH NeuroMab Facility

Director, T32 Training Program in Molecular and Cellular Biology

Member, Biochemistry, Cell, Developmental and Molecular Biology Graduate Group

Member, Neuroscience Graduate Group