Frank Sharp, M.D.

 Frank  Sharp, M.D.

Position

  • Professor
  • Neurology

Contact

Neurobiology of Stroke, Alzheimer’s and Other Diseases

Research Summary

Rodent Studies: Ischemic Stroke, Brain Hemorrhage, Blood Brain Barrier, Heat Shock Proteins, Apoptosis, Cell Stress, Hypoxia Blood Genomics. Our laboratory has pioneered the discovery of neurogenesis following stroke, re-entry of neurons into the cell cycle following ischemia, and the use of gene expression in blood to monitor brain injury.  

Rodent Studies: We have pioneered developing an animal model of sporadic Alzheimer’s Disease. Elements of this model are now being examined in human AD brain.

Human Studies: Blood Genomics of Ischemic Stroke, Brain Hemorrhage and Transient Ischemic Attacks

Human Studies: Gene Expression Changes in Brains of Individuals with Autism

Recent Publications

Inflammation Combined with Ischemia Produces Myelin Injury and Plaque-Like Aggregates of Myelin, Amyloid-β and AβPP in Adult Rat Brain. Zhan X, Cox C, Ander BP, Liu D, Stamova B, Jin LW, Jickling GC, Sharp FR. J Alzheimers Dis. 2015 May 30;46(2):507-23.

Myelin basic protein associates with AβPP, Aβ1-42, and amyloid plaques in cortex of Alzheimer's disease brain. Zhan X, Jickling GC, Ander BP, Stamova B, Liu D, Kao PF, Zelin MA, Jin LW, DeCarli C, Sharp FR. J Alzheimers Dis. 2015;44(4):1213-29.

Gene expression in peripheral immune cells following cardioembolic stroke is sexually dimorphic. Stamova B, Jickling GC, Ander BP, Zhan X, Liu D, Turner R, Ho C, Khoury JC, Bushnell C, Pancioli A, Jauch EC, Broderick JP, Sharp FR. PLoS One. 2014 Jul 18;9(7):e102550.

Distinctive RNA expression profiles in blood associated with Alzheimer disease after accounting for white matter hyperintensities. Bai Z, Stamova B, Xu H, Ander BP, Wang J, Jickling GC, Zhan X, Liu D, Han G, Jin LW, DeCarli C, Lei H, Sharp FR. Alzheimer Dis Assoc Disord. 2014 Jul-Sep;28(3):226-33.

Inhibition of SRC family kinases protects hippocampal neurons and improves cognitive function after traumatic brain injury. Liu da Z, Sharp FR, Van KC, Ander BP, Ghiasvand R, Zhan X, Stamova B, Jickling GC, Lyeth BG. J Neurotrauma. 2014 Jul 15;31(14):1268-76.

Hemorrhagic transformation after ischemic stroke in animals and humans. Jickling GC, Liu D, Stamova B, Ander BP, Zhan X, Lu A, Sharp FR. J Cereb Blood Flow Metab. 2014 Feb;34(2):185-99.

RNA in blood is altered prior to hemorrhagic transformation in ischemic stroke. Jickling GC, Ander BP, Stamova B, Zhan X, Liu D, Rothstein L, Verro P, Khoury J, Jauch EC, Pancioli AM, Broderick JP, Sharp FR. Ann Neurol. 2013 Aug;74(2):232-40.

Prediction of cardioembolic, arterial, and lacunar causes of cryptogenic stroke by gene expression and infarct location. Jickling GC, Stamova B, Ander BP, Zhan X, Liu D, Sison SM, Verro P, Sharp FR. Stroke. 2012 Aug;43(8):2036-41.

Ischemic transient neurological events identified by immune response to cerebral ischemia. Jickling GC, Zhan X, Stamova B, Ander BP, Tian Y, Liu D, Sison SM, Verro P, Johnston SC, Sharp FR. Stroke. 2012 Apr;43(4):1006-12.

Effects of gender on gene expression in the blood of ischemic stroke patients. Tian Y, Stamova B, Jickling GC, Liu D, Ander BP, Bushnell C, Zhan X, Davis RR, Verro P, Pevec WC, Hedayati N, Dawson DL, Khoury J, Jauch EC, Pancioli A, Broderick JP, Sharp FR. J Cereb Blood Flow Metab. 2012 May;32(5):780-91

Transient ischemic attacks characterized by RNA profiles in blood. Zhan X, Jickling GC, Tian Y, Stamova B, Xu H, Ander BP, Turner RJ, Mesias M, Verro P, Bushnell C, Johnston SC, Sharp FR. Neurology. 2011 Nov 8;77(19):1718-24.

Blood-brain barrier breakdown and repair by Src after thrombin-induced injury. Liu DZ, Ander BP, Xu H, Shen Y, Kaur P, Deng W, Sharp FR. Ann Neurol. 2010 Apr;67(4):526-33.

Affiliations

Neuroscience Graduate Group

Department of Neurology

Genetics Graduate Group

Molecular, Cellular and Integrative Physiology Graduate Group

Pharmacology and Toxicology Graduate Group 

Lab Members

Glen C Jickling MD, Assistant Professor

DaZhi Liu, PhD, Assistant Research Professor

Boryana Stamova PhD, Assistant Research Professor

Xinhua Zhan MD PhD, Associate Research Professor

Bradley Ander PhD, Associate Project Scientist

Heather Hull BS, Research Associate

Miles Orantia BS, Clinical Coordinator

Natasha Shroff, Graduate Student (Genetics)

Cheryl Dykstra-Aiello, Graduate Student (Molecular, Cellular and Integrative Physiology)

Xiyuan Anyuecheng, Graduate Student (Pharmacology and Toxicology)