Fuzheng Guo, Ph.D.

 Fuzheng  Guo, Ph.D.

Position

  • Assistant Professor
  • Neurology

Contact

Neural development; Glial differentiation, myelination, and demyelination in neurological disorders and animal models; Glia-Vascular Interrelations.

Research Summary

Our laboratory is currently studying how oligodendrocyte differentiation, myelination and remyelination are regulated during normal development and dysregulated in neurological disorders. Previous studies from our laboratory and others have shown that a signaling pathway called canonical Wnt/β-catenin signaling inhibits oligodendrocyte differentiation. TCF7l2, a known transcription factor mediating Wnt/β-catenin activity in Wnt responsive cells such as colorectal cancer cells, is postulated to inhibit oligodendrocyte differentiation and myelination through Wnt/β-catenin signaling. However, genetic data from both our laboratory and others suggest that TCF7l2 is an intrinsic positive regulator of oligodendrocyte development. Further genetic evidence from our laboratory indicates that TCF7l2 regulates postnatal oligodendrocyte development in a manner independent of Wnt/β-catenin signaling and that TCF7l2 promotes oligodendrocyte differentiation in demyelination animal models. Our study shifts the research direction of this transcription factor from a postulated myelination inhibitor to a positive regulator during oligodendrocyte development. The second project in our laboratory is studying interaction between oligodendroglia and vascular cells during normal CNS development and in neuroinflammatory diseases and the molecular basis for this interaction. Other projects in our lab are focused on transcriptional control of astroglial development and activation after neural injury. Please visit our laboratory website at Guo Laboratory Website