Gino Cortopassi, Ph.D.

 Gino  Cortopassi, Ph.D.

Position

  • Professor
  • Molecular Biosciences

Mitochondrial Function and Dysfunction in Human Aging and Disease

Research Summary

We study inherited mitochondrial genetic disease in terms of pathophysiological mechanism and potential therapeutics. Two main foci are mitochondrial neurodegenerative diseases, Friedreich's ataxia, and Leber's hereditary optic neuropathy. In both diseases there is an inherited mitochondrial defect that causes neurodegeneration. We study the pathophysiological mechanism using cell and animal models of the disease, RNAseq, microarray, QRTPCR, and biochemical assays. In the last 4 years we have used the genetically-based cellular defects to screen for drugs which may rescue the cellular defects and thus be relevant therapeutics. In this case the compounds need to be evaluated with respect to mechanism of pathophysiological rescue in cells and animals etc. We have a third project to understand the basis of leanness and 'healthy aging' in Shc knockout mice.

Affiliations

VM:Molecular Biosciences

CEHS-Center for Environmental Health Sciences
Genetics  

Biochemistry, Molecular, Cellular and Developmental Biology  

Neuroscience
 
Molecular, Cellular, and Integrative Physiology