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Program of StudyElective Courses Offered through other Graduate GroupsBIS 104 - 104. Regulation of Cell Function (3)Lecture--3 hours. Prerequisite: course 101 and 102; course 103 recommended. Membrane receptors and signal transduction; cell trafficking; cell cycle, cell growth and division; extracellular matrix and cell-cell junctions; cell development; immune system.-- Baskin, Crowe, Etzler, McNally, Myles, Nuccitelli, Privalsky, Scholey, Shiozaki BIM 241. Introduction to Magnetic Resonance Imaging (3) Lecture--3 hours. Prerequisite: Physics 9D, Mathematics 22B. Equipment, methods, medical applications of MRI. Lectures review basic, advanced pulse sequences, image reconstruction, display and technology and how these are applied clinically. Lecture complements a more technical course. Buonocore BIM 246. Magnetic Resonance Technology (3) Lecture--3 hours. Prerequisite: Physics 9D, Mathematics 22B. Course covers MRI technology at an advanced level with emphasis on mathematical descriptions and problem solving. Topics include spin dynamics, signal generation, image reconstruction, pulse sequences, biophysical basis of T1, T2, RF, gradient coil design, signal to noise, image artifacts Buonocore Fundamentals of Clinical Psychiatry 403 This course gives a great overview of different psychiatric disorders, their diagnoses and treatment. Consistently entertaining lectures with fascinating videos. This course includes weekly trips to the Sacramento Mental Health Treatment Center. There you meet with and interview patients in some unforgettable encounters. I don't recommend taking this for credit, though. The exams are very Pharm-intensive, so unless you know psychiatric medications like the back of your hand, audit this one. Course web page: http://medocs.ucdavis.edu/psy/403/index.htm ECS 030 - Introduction to Programming and Problem Solving (4) Lecture--3 hours; discussion--1 hour. Prerequisite: Mathematics 16A or 21A (may be taken concurrently); prior experience with basic programming concepts (variable, loops, conditional statements) recommended. Introduction to computers and computer programming, algorithm design, and debugging. Elements of good programming style. Programming in the C language. Use of basic UNIX tools Ruschitzka EDO 218. Mammalian Endocrinology and Homeostasis (4) Lecture--4 hours. Prerequisite: Biological Sciences 102 and 103, Neurobiology, Physiology and Behavior 101, and consent of instructor. Biochemical, physiological, and regulatory properties of the mammalian endocrine system, at the molecular, cellular and systemic level. Signal transduction mechanisms and hormonal actions. Principles that regulate homeostasis, especially in organ_organ interrelationships, metabolism and minerals, fluids and electrolytes. Reproductive endocrinology Turgeon GGG 201B. Cytogenetics (3) Lecture--3 hours. Prerequisite: course 201A or consent of instructor. Study of cytogenetics including meiosis, recombination, chromosomes, haploidy, aneuploidy, trisomics, monosomics, autopolyploids and intra- and interspecific manipulation GGG 201C. Molecular Genetics (3) Lecture--3 hours. Prerequisite: course 201A or consent of instructor. Current topics in molecular genetics at a graduate level, with emphasis on the relationship between classical genetic studies and current molecular research, as well as on the molecular techniques used to develop the basic concepts of molecular genetics GGG 201D. Quantitative and Population Genetics (3) Lecture--3 hours. Prerequisite: course 201A or consent of instructor. The basic concepts of quantitative and population genetics, including gene and genotypic frequencies, multiple factor hypothesis, phenotypic and genotypic values, heritability, selection, genetic variation and evolution in populations, and experimental methodologies MAT 227. Scientific Computation Applied to Problems in Biology (4) Lecture--4 hours. Prerequisite: graduate standing or consent of instructor. Numerical solution of differential equations is studied using programming environments such as Maple, Mathematica and Matlab. Emphasis on understanding why numerical algorithms work. Particular attention to the application of these algorithms to problems in biology MAT 222. Introduction to Biofluid Dynamics (3) Lecture--3 hours. Prerequisite: Population Biology 231/Ecology 231 and Neurobiology, Physiology and Behavior 245 or consent of instructor. The basic principles of fluid dynamics are introduced in the first half of the course by describing various phenomena studies from a biofluids perspective. The equations of fluid motion associated with these phenomena are derived and studied in the second half MCB 241. Membrane Biology (3) Lecture--3 hours. Prerequisite: Biological Sciences 102, 104, or consent of instructor. Advanced topics on membrane biochemistry and biophysics. How the unique properties of biomembranes relate to various roles in cell biology and physiology Crowe, Voss MCB 255. Molecular Mechanisms in Animal Development (3) Lecture--1.5 hours; seminar--1.5 hours. Prerequisite: graduate standing or consent of instructor; introductory background in developmental biology and molecular genetics recommended. Analysis of the molecular mechanisms that control animal development, with a special focus on multiple levels of gene regulation. Experimental systems including Drosophila, amphibians, C. elegans, and mice will be discussed. Readings will be taken from current literature. Offered in alternate years Natzle, L. Rose, Spicer MCB 262. Transgenic Expression Systems (3) Lecture--3 hours. Prerequisite: Biological Sciences 101 and course 161 or consent of instructor. The molecular biology underlying current transgenic expression systems. Strategies for achieving regulated expression and secretion of proteins. Survey of bacterial, yeast, insect cell, mammalian cell, plant and animal expression systems. Offered in alternate years. Rodriguez MCB 298 - Bioinformatics (Lagarias, Rosenquist) MCB 221D. Cellular Biochemistry (4) Lecture--3 hours; discussion--1 hour. Prerequisite: course 221A. Molecular structure and biochemical function of cell membranes, cytoplasmic organization, organelle trafficking, signaling, mechanisms of intracellular transport, chromosome segregation and cell division with emphasis on biochemical principles Etzler, Privalsky, Scholey, Voss MCB 241. Membrane Biology (3) Lecture--3 hours. Prerequisite: Biological Sciences 102, 104, or consent of instructor. Advanced topics on membrane biochemistry and biophysics. How the unique properties of biomembranes relate to various roles in cell biology and physiology Crowe, Voss MCB 255. Molecular Mechanisms in Animal Development (3) Lecture--1.5 hours; seminar--1.5 hours. Prerequisite: graduate standing or consent of instructor; introductory background in developmental biology and molecular genetics recommended. Analysis of the molecular mechanisms that control animal development, with a special focus on multiple levels of gene regulation. Experimental systems including Drosophila, amphibians, C. elegans, and mice will be discussed. Readings will be taken from current literature. Offered in alternate years. Natzle, L. Rose, Spicer NPB 245. Computational Models of Cellular Signaling (3) Lecture--3 hours. Prerequisite: consent of instructor. Computational and mathematical techniques in modeling of regulatory and signaling phenomena in neurobiology and cell physiology, focusing on linear and nonlinear ordinary differential equation models. Applications include ion channel kinetics, electrical activity, signal transduction, calcium oscillations, and simple neural circuits. Mogilner NPB 101L - Systemic Physiology Lab Laboratory--3 hours; discussion--2 hours. Prerequisite: course 101 prior to taking 101L recommended, but 101 may be taken concurrently. Selected experiments to illustrate functional characteristics of organ systems discussed in course 101. Adamson, Goldberg PBG 231. Mathematical Methods in Population Biology (3) Lecture--3 hours. Prerequisite: Mathematics 16C or 21C or the equivalent. Mathematical methods used in population biology. Linear and nonlinear difference equation and differential equation models are studied, using stability analysis and qualitative methods. Partial differential equation models are introduced. Applications to population biology models are stressed. (Same course as Ecology 231) Hastings PBG 200B. Principles of Population Biology (6) Lecture--5 hours; discussion--1 hour. Prerequisite: course 200A, 231. Principles of multi-species communities. Topics include competition, mutualism, metapopulations, food webs and trophic cascades, interactions between simple ecological communities, island biogeography, succession, and large-scale patterns. PBG 200C. Principles of Population Biology (6) Lecture--5 hours; discussion--1 hour. Prerequisite: course 200B. Principles of microevolution and macroevolution. Topics include evolutionary quantitative genetics, analysis of hybrid zones, speciation, the fossil record, biogeography, and phylogeny reconstruction. PBI 223. Special Topics in Scientific Method (2) Discussion--2 hours. Examine the historical and philosophical background of the scientific method. Analyze the rational, perceptual, causal, creative and social aspects of scientific knowledge. Clarify the roles of reason, experimentation and creativity in scientific research. (S/U grading only.) Bradford PGG 214. Neurophysiology (4) Lecture--4 hours. Prerequisite: Neurobiology, Physiology and Behavior 111B, 112; consent of instructor. Electrical activity of neurons and neuroeffector junctions; physiology of the nervous system as studied by its electrical activity.--II. (II.) Carstens PGG 216. Neurophysiology Literature (3) (may be the same as NPB 216) Lecture--1 hour; discussion--2 hours. Lectures covering experimental and theoretical methods in studying cell membrane ion channels and the resulting characterization of the physiological functions and structure/function relationships of some of the most important channel types. Discussion of classical and current original papers.--I. (I.) Pappone PGG 217. The Vertebrate Eye (2) Seminar--1 hour; lecture/discussion--1 hour. Prerequisite: graduate standing and a background in biology; Neurobiology, Physiology and Behavior 120F strongly recommended. Physiology, biochemistry, and biology of the vertebrate eye with emphasis on the retina, particularly photoreceptors. A comparative approach will be taken with adaptations in ocular function related to behavior and environment. May be repeated for credit with consent of instructor. Offered in alternate years.--II. Sillman PGG 200L. Animal Cell Culture Laboratory (4) Discussion--2 hours; laboratory--6 hours. Prerequisite: courses in undergraduate biochemistry, cell biology, or general physiology, or consent of instructor. Techniques of cell culture, with emphases on cell physiology and the actions of drugs and toxicants on cultured somatic cells. Design, performance and interpretation of experiments with animal cells in vitro.--II. (II.) B. Wilson, R. Wu PGG 242. Biological Rhythms (3) Lecture--2 hours; lecture/discussion--1 hour. Prerequisite: Neurobiology, Physiology and Behavior 110 or the equivalent. General aspects and basic mechanisms of biological rhythms; the importance of rhythm desynchronization in areas of pharmacology and space medicine; telemetry; mathematical methods; chronometry; daily, reproductive, and annual periods; shift-work, jet lag and sleep disorders. Offered in alternate years.--(I.) Fuller PGG 291D. Research Approaches in Physiology (2) Seminar--2 hours. Prerequisite: graduate standing in Graduate Group in Physiology or consent of instructor. Current research in physiology. Overall design of experiments and particular research areas. (S/U grading only.)--I. (I.) PGG 390 The Teaching of Physiology (1) Discussion--1 hour. Prerequisite: Teaching Assistant assignment to a physiology lecture course and consent of instructor. Practical experience in methods and problems of teaching physiology lecture courses. May include analyses of texts and supporting material, discussion of teaching techniques, preparing for and conducting discussion sessions, and formulation of topics and questions for examinations under supervision of instructor. May be repeated for credit. (S/U grading only.)--I, II, III. (I, II, III.) PGG 231. Neuroendocrinology (3) Lecture--3 hours. Prerequisite: Neurobiology, Physiology and Behavior 110 or the equivalent course in systemic physiology; Neurobiology, Physiology and Behavior 130 or the equivalent course in endocrinology. Neural-endocrine interactions; neural regulation of the endocrine system, especially in relation to reproduction; the role of hormones and growth factors in sexual differentiation of the brain.--II. (II.) PGG 234. Neurophysiological Basis of Neurotoxicology (3) Lecture--3 hours. Prerequisite: Neurobiology, Physiology and Behavior 110 or the equivalent; basic understanding of neurophysiology. Mechanisms of action at the cellular and systemic level of a number of different neurotoxins and toxicants. Examples of ways toxins may act on the nervous system and techniques for study of neurotoxicology. (Same course as Environmental Toxicology 234.)--III. (III.) Wooley PGG 214. Neurophysiology (4) Lecture--4 hours. Prerequisite: Neurobiology, Physiology and Behavior 111B, 112; consent of instructor. Electrical activity of neurons and neuroeffector junctions; physiology of the nervous system as studied by its electrical activity. Carstens PSC 131. Perception (4) Lecture--3 hours; independent library work. Prerequisite: courses 1, 41. The cognitive organizations related to measurable physical energy changes mediated through sensory channels. The perception of objects, space, motion, events.--I, II, III. (I, II, III.) Parks, Post PSC 163 - Mathematical Modeling PSC 290 - Neural Networks (adjunct to seminar series) (Olshausen) PSC 204B Causal Model Corr Data (4 units/ Simonton) (winter) see http://psychology.ucdavis.edu/simonton/p204bwmain.html for the lowdown PSC 220 History of Psychology (4.0 / Simonton) (winter) see http://psychology.ucdavis.edu/simonton/p185wmain.html for the lowdown. PSC 204A. Statistical Analysis of Psychological Experiments (4) Lecture--4 hours. Prerequisite: graduate standing in Psychology or consent of instructor. Probability theory, sampling distributions, statistical inference, and hypothesis testing using standard parametric and correlational approaches. Analysis of variance, factorial and repeated measures, and tests of trends. Not open for credit to students who have completed course 206. (Former course 206.)--I. (I.) PTX 201. Principles of Pharmacology and Toxicology I (5) Lecture--5 hours. Prerequisite: Biological Sciences 102 and Neurobiology, Physiology and Behavior 101. First of three courses presenting fundamental principles of pharmacology and toxicology. Introductory overview of basic concepts in pharmacology/toxicology, followed by in-depth blocks on fate processes of chemicals in the body, fate processes in tissue selective responses, selective toxicity employed therapeutically.--I. (I.) PTX 202. Principles of Pharmacology and Toxicology II (4) Lecture--4 hours. Prerequisite: course 201. The second of three courses presenting fundamental principles of pharmacology and toxicology. Principles of pharmacodynamics and mechanisms of drug/toxicant actions.--II. (II.) PTX 203. Principles of Pharmacology and Toxicology (4) Lecture--4 hours. Prerequisite: courses 201 and 202. Integrated physiological systems, cardiovascular and nervous systems and how drugs and toxicants act to perturb function.--III. (III.) STA 100 - Applied Statistics for Biological Sciences (4) Lecture--3 hours; laboratory--2 hours. Prerequisite: Mathematics 16B or the equivalent. Probability computation/modeling, estimation, hypothesis testing, contingency tables, ANOVA, regression; implementation of statistical methods using computer package. Only two units credit allowed to students who have taken course 13 or 32. Not open for credit to students who have taken course 102. GE credit SciEng.--I, II, III. (I, II, III.) STA 104. Applied Statistical Methods: Nonparametric Statistics (4) Lecture--3 hours; laboratory--1 hour. Prerequisite: course 13, 32, or 102. Sign and Wilcoxon tests, Walsh averages. Two-sample procedures. Inferences concerning scale. Kruskal-Wallis test. Measures of association. Chi square and Kolmogorov-Smirnov tests. Offered in alternate years. GE credit: SciEng.--(II.) STA 106. Applied Statistical Methods: Analysis of Variance (4) Lecture--4 hours. Prerequisite: course 13, 32, or 102. One-way and two-way fixed effects analysis of variance models. Randomized complete and incomplete block design, Latin squares. Multiple comparisons procedures. One-way random effects model. GE credit: SciEng.--I, II. (I, II.) STA 108. Applied Statistical Methods: Regression Analysis (4) Lecture--3 hours; discussion--1 hour. Prerequisite: course 13, 32 or 102. Simple linear regression, variable selection techniques, stepwise regression, analysis of covariance, influence measures, computing packages. GE credit: SciEng.--I, II, III. (I, II, III.) |
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