Konstantinos Zarbalis, Ph.D.

 Konstantinos  Zarbalis, Ph.D.


  • Assistant Professor
  • Pathology and Laboratory Medicine

Forebrain Development with Emphasis on Migration, Differentiation, and Connectivity of Cortical Neurons

Select Publications

Zarbalis K., Choe, Y., Siegenthaler J. A., Orosco L. A., Pleasure S. J. Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice. Neural Development (2012), in press.

Endoh-Yamagami S., Karkar K. M., May S. R., Cobos I., Thwin M. T., Long J. E., Ashique A. A., Zarbalis K., John L.R. Rubenstein, Andrew S. Peterson. A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice. Dev. Biol. 340 (2010) 41-53.

Wizenmann A., Brunet I., Lam J., Sonnier L., Beurdeley M., Zarbalis K., Weisenhorn-Vogt D., Weinl C., Dwivedy A., Joliot A., Holt C., Wurst W., Prochiantz A. Extracellular Engrailed participates in the topographic guidance of retinal axons in vivo. Neuron 64 (2009) 355-366.

Siegenthaler J. A., Ashique A. M.*, Zarbalis K.*, Patterson K. P., Hecht J. H., Kane M. A., Folias A. E., Choe Y., May S. R., Kume T., Napoli J. L., Peterson A. S., Pleasure S. J. Retinoic acid from the meninges regulates cortical neuron generation. Cell 139 (2009) 597-609.

Zarbalis K.*, Siegenthaler J. A.*, Choe Y., May S. R., Peterson A. S., Pleasure S. J.: Cortical dysplasia and skull defects in mice with a novel Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development. PNAS 104 (2007) 14002–14007.

Konstantinova I., Nikolova G., Ohara-Imaizumi M., Meda P., Kucera T., Zarbalis K., Wurst W., Nagamatsu S., Lammert E.: EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell 129 (2007) 359-370.

Dow L. E., Kauffman J. S., Caddy J., Zarbalis K., Peterson A. S., Jane S. M., Russell S. M., Humbert P. O.:  The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge. Oncogene 26 (2007) 2272-2282 [with correction in 26 (2007) 5692].

May S. R., Ashique A. M., Karlenc M., Wang B., Shen Y., Zarbalis K., Reiter J., Ericson J., Peterson A. S.: Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev Biol. 287 (2005) 378-89.

Zarbalis, K.*, May, R. S.*, Shen, Y., Ekker, M., Rubenstein, J. L. R., Peterson, A.: A focused and efficient genetic screening strategy in the mouse: Identification of mutations that disrupt cortical development.  PLoS Biology 2 (2004) 1177-1187.

Bolz, J., Mühlfriedel, S., Güllmar, A., Peuckert, C., Zarbalis, K., Wurst, W., Masaaki, T., Levitt, P.: Multiple roles of ephrins during the formation of thalamocortical projections: Maps and more.  J. Neurobiol. 59 (2004) 82-94.

Uziel D., Mühlfriedel S., Zarbalis K., Wurst W., Levitt P., Bolz J.: Miswiring of limbic thalamocortical projections in the absence of ephrin-A5. J. Neurosci. 22 (2002) 9352-9357.

Knöll B.*, Zarbalis K.*, Wurst W., Drescher U.: A role for the EphA family in the topographic targeting of vomeronasal axons. Development 128 (2001) 895-906.

Zarbalis K. and Wurst W.: Expression domains of murine ephrin-A5 in the pituitary and hypothalamus. Mech. Dev. 93 (2000) 165-168.

* equal contribution


Department of Pathology and Laboratory Medicine

Shriners Hospitals for Children