Tony Simon, Ph.D.

 Tony  Simon, Ph.D.

Position

  • Professor
  • Psychiatry and Behavioral Sciences

Brain and Cognition, Neurodevelopmental Disorders, Psychosis

Research Summary

Dr. Simon is a pediatric cognitive neuroscientist. His research focuses on the interactions between neural, cognitive, affective and stress biology differences in young people with genetic disorders that produce learning difficulties, behavioral dysregulation and psychopathology. Dr. Simon has spent over a decade and a half investigating how dysfunction in specific neurocognitive processing systems, such as attention, and spatial or temporal processing generates cognitive impairments in thinking about space, time, numbers as was as real world challenges like math, using money and navigation. He has developed and is testing a digital neurotherapeutic intervention (in the form a video game) to minimize such disability.  Dr. Simon's current main project is a National Institute of Mental Health funded longitudinal study on risk and protective factors for psychosis proneness in chromosome 22q11.2 deletion (Velocardiofacial/DiGeorge) syndrome based on the interaction of neurocognitive and affective processing and stress reactivity. Besides experimental cognitive processing analyses, Dr. Simon uses cutting edge neuroimaging methods, such as resting state functional magnetic resonance imaging (rs-fMRI), Diffusion Tensor Fiber Tracking as well as Event-Related Potential (ERP) components of electrophysiological studies in order to study the structure, function and connective patterns in the developing brain.

Select Publications

Wong L.M., Tassone F, Rivera, S.M. Simon T.J. Temporal dynamics of attentional selection in adult male carriers of the fragile X premutation allele. (2015). Frontiers in Human Neuroscience, 9, 37. DOI: 10.3389/fnhum.2015.00037

Stephenson, D.D., Beaton, E.A., Weems, C.F., Angkustsiri, K., Simon, T.J. (2014) Identifying patterns of anxiety and depression in children with chromosome 22q11.2 deletion syndrome: Co-morbidity predicts behavioural difficulties and impaired functional communications. Behavioral Brain Research, 276, 190-198. DOI: 10.1016/j.bbr.2014.05.056

Wong LM, Goodrich-Hunsaker NJ, McLennan, Y., Tassone F, Zhang M, Rivera SM, Simon TJ.(2014) Eye movements reveal impaired inhibitory control in adult male fragile X premutation carriers asymptomatic for FXTAS. Neuropsychology 28, 571–584 DOI10.1037/neu0000066

Leow, A., Harvey, D., Goodrich-Hunsaker, N., Gadelkarim, J., Kumar, A., Zhan, L., Rivera, S.M.,Simon, T.J. (2014) Altered Structural Brain Connectome Properties In Young Adult Fragile X Premutation Carriers. Human Brain Mapping, 35, 4518-530 DOI: 10.1002/hbm.22491

Wong LM, Goodrich-Hunsaker NJ, McLennan Y, Tassone F, Rivera, S.M., Simon T.J. (2014). A cross-sectional analysis of orienting of visuospatial attention in child and adult carriers of the fragile X permutation. Journal of Neurodevelopmental Disorders, 6, 45. DOI: 10.1186/1866-1955-6-45

Schneider, M., Debbané, M., Bassett, A.S., ChowE.W.C., Fung, W., van den Bree, M., Owen, M., Murphy, K.C., Niarchou, M., Kates, W.R., Antshel, K.M., Fremont, W,. McDonald-McGinn, D.M., Gur, R.E, Zackai, E.H., Vorstman, J., Duijff, S.N., Klaassen, P.S, Gothelf, D., Green, T., Weizman, A., Van Amelsvoort, T., Evers, R., Boot, E., Shashi, V., Hooper, S.R., Bearden, C.E., Jalbrzkowski, M., Armando, M., Vicari, S., Murphy, D.G., Ousley, O., Campbell, L.E., Simon, T.J., Eliez, S. and the International 22q11.2 Deletion Syndrome Consortium. (2014) Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome (22q11.2DS): Results from the International 22q11.2 Deletion Syndrome Consortium psychiatric platform. American Journal of Psychiatry.DOI:10.1176/appi.ajp.2013.13070864

Shapiro H.M., Tassone, F., Choudhary, N., Simon, T.J. (2014) The development of cognitive control in children with chromosome 22q11.2 deletion syndrome. Frontiers in Psychology; Developmental Psychology DOI: 10.3389/fpsyg.2014.00566

Quintero, A.I., Beaton, E.A., Harvey, D.J., Ross, J.L., Simon, T.J. (2014) Common and specific impairments in attention functioning in girls with chromosome 22q11.2 deletion, fragile X, or Turner syndromes. Journal of Neurodevelopmental Disorders, 6, 5, DOI:10.1186/1866-1955-6-5

Wong LM, Riggins T, Harvey D, Cabaral M, Simon TJ. (2014Children with chromosome 22q11.2 deletion syndrome exhibit impaired spatial working memory. American Journal of Intellectual and Developmental Disabilities119, 115-132, DOI: 10.1352/1944-7558-119.2.115

Angkustsiri, K., Goodlin-Jones, B., Deprey, L., Brahmbatt, K., Harris, S., Simon, T.J. Social impairments in 22q11.2DS: Autism Spectrum Disorder or a different endophenotype? (2014) Journal of Autism and Developmental Disorders. 44, 439-746.

Shapiro, H., Wong, L., Simon, T.J. (2013) A cross-sectional analysis of the development of response inhibition in children with chromosome 22q11.2 deletion syndrome. Frontiers in Child and Neurodevelopmental Psychiatry. 4, 81. DOI: 10.3389/fpsyt.2013.00081

Wong, L.M., Goodrich-Hunsaker, N.J., McLennan, Y., Tassone, F., Harvey, D., Rivera, S.M., Simon, T.J. (2012) Young adult male carriers of the fragile X premutation exhibit genetically modulated impairments in visuospatial tasks controlled for psychomotor speed. Journal of Neurodevelopmental Disorders. 4:26. DOI: 10.1186/1866-1955-4-26

Angkustsiri, K., Tartaglia, N.R., Leckliter, I., Enriquez, J., Hansen, R.L., Beaton, E.A., Simon, T.J. (2012) An examination of the relationship of anxiety and intelligence to adaptive functioning of children with chromosome 22q11.2 deletion syndrome. Journal of Development and Behavioral Pediatrics. 33, 713-720. DOI: 10.1097/DBP.0b013e318272dd24

Cabaral, M.H., Beaton, E.A., Stoddard, J.J., Simon, T.J. (2012) Impaired multiple object tracking in children with chromosome 22q11.2 deletion syndrome. Journal of Neurodevelopmental Disorders. 4:6, DOI:10.1186/1866-1955-4-6

Shapiro, H.M., Takarae, Y., Harvey, D., Cabaral, M., Simon, T.J. (2012) A Cross-sectional study of the development of volitional control of spatial attention in children with chromosome 22q11.2 deletion syndrome. Journal of Neurodevelopmental Disorders. 4:5, DOI: 10.1186/1866-1955-4-5

Stoddard, J., Takarae, Y., Simon, T.J. (2012) A second look: No effect of the COMT Val158Met single nucleotide polymorphism on adaptation to flanker interference in youth with chromosome 22q11.2 deletion syndrome. Schizophrenia Research.

Nordahl, C.W., Scholz, R., Yang, X., Buonocore, M., Simon, T.J., Rogers, S.J. Amaral, D.G. (2012) Increased rate of amygdala growth in 2-4 year olds with autism: a longitudinal study. Archives of General Psychiatry. 69, 53-61.

Srivastava, S., Buonocore, M., Simon, T.J. (2012) Atypical developmental trajectory of functionally significant cortical areas in children with chromosome 22q11.2 deletion syndrome. Human Brain Mapping, 33, 213-233. DOI: 10.1002/hbm.21206

Guo T, McDonald-McGinn D, Blonska A, Shanske A, Bassett AS, Chow E, Bowser M, Sheridan M, Beemer F, Devriendt K, Swillen A, Breckpot J, Digilio MC, Marino B, Dallapiccola B, Carpenter C, Zheng X, Johnson J, Chung J, Higgins AM, Philip N, Simon TJ, Coleman K, Heine-Suner D, Rosell J, Kates W, Devoto M, Goldmuntz E, Zackai E, Wang T, Shprintzen R, Emanuel B, Morrow B; International Chromosome 22q11.2 Consortium. (2011) Genotype and cardiovascular phenotype correlations with TBX1 in 1,022 velo-cardio-facial/DiGeorge/22q11.2 deletion syndrome patients. Hum Mutat. Nov;32(11):1278-89. doi: 10.1002/humu.21568.

Nordahl, C.W., Lange, N., Li, D., Barnett, L.A., Lee, A., Buonocore, M., Simon, T.J., Rogers, S.J., Ozonoff, S. Amaral, D.G. (2011) Brain enlargement is associated with regression in preschool age boys with autism. Proceedings of the National Academy of Sciences. 108, 20195-20200.

Simon, T.J. (2011) Clues to the Foundations of Numerical Cognitive Impairments: Evidence from Genetic Disorders. Developmental Neuropsychology, 36, 788-805. DOI:10.1080/87565641.2010.54987

Goodrich-Hunsaker. N.J., Wong, L., McLennan, Y., Tassone, F., Harvey, D., Rivera, S.M., Simon, T.J. (2011) Adult female fragile X premutation carriers exhibit age- and CGG repeat length-related impairments on an attentionally-based enumeration task. Frontiers in Human Neuroscience, 5, 63 DOI: 10.3389/fnhum.2011.00063

Goodrich-Hunsaker. N.J., Wong, L., McLennan, Y., Srivastava, S., Tassone, F., Harvey, D., Rivera, S.M., Simon, T.J. (2011) Enhanced manual and oral motor reaction time in young adult female fragile X premutation carriers. Journal of the International Neuropsychological Society, 17, 746-750.

Goodrich-Hunsaker. N.J., Wong, L., McLennan, Y., Srivastava, S., Tassone, F., Harvey, D., Rivera, S.M., Simon, T.J. (2011) Young adult female fragile X premutation carriers show age- and genetically-modulated cognitive impairments. Brain & Cognition, 75, 255-260.

Stoddard, J., Beckett, L., Simon, T.J. (2011) Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome. Journal of Neurodevelopmental Disorders. 3, 76-85.

Beaton, E.A. & Simon, T.J. (2011) How might stress contribute to increased risk for schizophrenia in children with chromosome 22q11.2 deletion syndrome? Journal of Neurodevelopmental Disorders. 3, 68-75.

Stoddard, J., Niendam, T., Hendren, R., Carter, C., Simon, T.J. (2010) Attenuated positive symptoms of psychosis in adolescents with chromosome 22q11.2 deletion syndrome. Schizophrenia Research, 118: 118-121

Karayiorgou, M., Simon, T.J., Gogos, J.A. (2010) 22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia. Nature Reviews Neuroscience. 11,  402-16

Beaton, E. A., Stoddard, J., Lai, S., Lackey, J., Shi, J., Ross, J.L., Simon, T.J. (2010). Atypical functional brain activation during a multiple object tracking task in girls with Turner syndrome: Neurocorrelates of reduced spatiotemporal resolution. American Journal on Inellectual and Developmental Disabilities 115, 2: 140-156

Takarae, Y., Schmidt, L., Tassone, F., Simon, T.J.(2009) Catechol-O-methyltransferase polymorphism modulates cognitive control in children with chromosome 22q11.2 deletion syndrome. Cognitive and Behavioral Neuroscience 9, 83-90. 

Simon, T.J., Wu, Z., Avants, B., Zhang, H., Gee, J.C., Stebbins, G.T. (2008) Atypical Cortical Connectivity and Visuospatial Cognitive Impairments are Related in Children with Chromosome 22q11.2 Deletion Syndrome. Behavioral and Brain Functions, 4: 25.

Simon, T.J. (2008) A New Account of the Neurocognitive Foundations of Impairments in Space, Time and Number Processing in Children with Chromosome 22q11.2 Deletion Syndrome. Developmental Disabilities Research Reviews. 14, 52-58.

Simon, T.J., Takarae, Y., DeBoer, T.L., McDonald-McGinn, D.M., Zackai, E.H., Ross, J.L. (2008) Overlapping Numerical Cognition Impairments In Children With Chromosome 22q11.2 Deletion Or Turner Syndromes. Neuropsychologia, 46, 82-94.

DeBoer, T., Wu, Z., Lee, A., Simon, T.J. (2007) Hippocampal Volume Reduction in Children with Chromosome 22q11.2 Deletion Syndrome is Associated with Cognitive Impairment. Behavioral and Brain Functions, 23: 54.

Machado, A.M.C., Simon, T.J., Nguyen, V., McDonald-McGinn, D.M., Zackai, E.H., Gee, J.C. Corpus callosum morphology and ventricular size in chromosome 22q11.2 deletion syndrome. (2007) Brain Research. 1131, 197-210.

Bish, J.P., Pendyal, A., Ding, L., Ferrante, H., Nguyen, V., McDonald-McGinn, D.M., Zackai, E.H., & Simon, T.J. (2006) Specific cerebellar reductions in children with chromosome 22q11.2 deletion syndrome. Neuroscience Letters. 399, 245-248.

Simon, T.J., Bearden, C.E., McDonald-McGinn, D., & Zackai, E. (2005) Visuospatial and numerical cognitive deficits in children with Chromosome 22q11.2 Deletion Syndrome. Cortex, 41: 131-141.

Simon, T.J., Ding, L., Bish, J.P., McDonald-McGinn, D., Zackai, E.H., & Gee, J. (2005) Volumetric, connective and morphologic changes in the brains of children with chromosome 22q11.2 deletion syndrome: An integrative study. NeuroImage, 25: 169-180.

Simon, T.J., Bish, J.P., Bearden, C.E., Ferrante, S., Ding, L., Nguyen, V., Gee, J., McDonald-McGinn, D., Zackai, E.H., & Emanuel, B. (2005) A multi-level analysis of cognitive dysfunction and psychopathology associated with chromosome 22q11.2 deletion syndrome in children. Development and Psychopathology. 17, 753-784.

Bish, J.P., Ferrante, S., McDonald-McGinn, D., Zackai, E.H., & Simon, T.J. (2005) Maladaptive conflict monitoring as evidence for executive dysfunction in children with chromosome 22q11.2 deletion syndrome. Developmental Science, 8: 36-43.

Bish, J.P., Nguyen, V., Ding, L., Ferrante, S., & Simon, T.J. (2004) Thalamic reductions in children with chromosome 22q11.2 deletion syndrome. NeuroReport, 15, 1413-1415.

Bish, J.P., Pendyal, A., Ding, L., Ferrante, H., Nguyen, V., McDonald-McGinn, D.M., Zackai, E.H., & Simon, T.J. (2006) Specific cerebellar reductions in children with chromosome 22q11.2 deletion syndrome. Neuroscience Letters. 399, 245-248.

Bearden, C.E., Jawad, A.F., Lynch, D.R., Sokol, S., Kanes, S.J., McDonald-McGinn, D., Saitta, S., Harris, S., Moss, E.M., Wang, P.P., Zackai, E., Emanuel, B.S., & Simon, T.J. (2004) Effects of function COMT polymorphism on prefrontal cognitive function in the 22q11.2 deletion syndrome. American Journal of Psychiatry, 161, 1700-1702.

Bearden, C.E., Jawad, A.F., Lynch, D.R., Monterosso, J.R., Sokol, S., McDonald-McGinn, D., Saitta, S., Harris, S., Moss, E.M., Wang, P.P., Zackai, E., Emanuel, B.S., & Simon, T.J. (2005) Effects of COMT genotype on behavioral symptomatology in the 22q11.2 deletion syndrome. Child Neuropsychology, 11(1), 109-117.

Affiliations

MIND Institute

Department of Psychiatry and Behavioral Sciences

Neuroscience

Center for Mind and Brain