Bruce Lyeth, Ph.D.

 Bruce  Lyeth, Ph.D.


  • Professor Emeritus
  • Neurological Surgery


Pathophysiology of Traumatic Brain Injury

Research Summary

My laboratory uses a variety of pharmacological, surgical, neuroanatomical, and behavioral methods to investigate the neural mechanisms involved in traumatic brain injury pathology. A major research effort examines excitotoxic cascades affecting cell survival and behavior. The ultimate goal of my research program is to develop novel therapeutic strategies targeted at reducing the debilitating consequences of traumatic brain injury. Pre-clinical testing of novel therapeutic strategies and compounds are routinely performed in my laboratory. Previous efforts have led to ongoing clinical trials evaluating hypothermia and glutamate receptor antagonists as therapeutic interventions for traumatic brain injury patients.

Select Publications

Gurkoff GG, Shahlaie K, Lyeth BG, Berman RF. Voltage-Gated Calcium Channel Blockers for The Treatment of Traumatic Brain Injury. In K.A. Heidenreich, Ed. New Therapeutics for Traumatic Brain Injury, Elsevier: Amsterdam, pp.179-197, 2017.

Berman RF, Lyeth BG, Shahlaie K, Gurkoff GG. Memory Disruption Following Traumatic Brain Injury.  In P.A, Jackson, A.A. Chiba, R.F. Berman, M.E. Ragozzino, Eds. The Neurobiological Basis of Memory, Springer International Publishing: Switzerland, pp. 283-320, 2016.

Van, KC and Lyeth BG. Lateral (Parasagittal) Fluid Percussion Model of Traumatic Brain Injury. In F. H. Kobeissy, C.E. Dixon,  R.L. Hayes & S. Mondello, Eds. Injury Models of Central Nervous System: Methods and Protocols. Humana Press: New York,  pp. 231-251, 2016.

Lyeth BG.  Application of Novel Therapeutic Agents for CNS Injury: NAAG Peptidase Inhibitors. In F. Kobeissy, Ed. Brain Injury Principles: Molecular, Neuropsychological, and Rehabilitation Aspects in Brain Injury Models, CRC Press: Boca Raton, FL, pp.549-560, 2015.

Abdul-Wahab R, Neuberger EJ, Lyeth BG, Santhakumar V, Pfister BJ. Fluid Percussion Injury Device for the Precise Control of Injury Parameters. J Neuroscience Methods 248:16-26, 2015.

Huang X-J,  Glushakova O,  Mondello S, Van K,  Hayes RL,  Lyeth BG. Acute Temporal Profiles of serum levels of UCH-L1 and GFAP and Relationships to Neuronal and Astroglial Pathology Following Traumatic Brain Injury in Rats. J Neurotrauma 32(16):1179-1189, 2015.

Lee DJ, Gurkoff GG, Izadi A, Seidl, SE, Echeverri A, Melnik M, Berman RF, Ekstrom AD, Muizelaar JP, Lyeth BG, Shahlaie K.  Septohippocampal neuromodulation improves cognition after traumatic brain injury. J Neurotrauma 32(22):1822-1832, 2015.

Liu D-Z, Sharp FR, Van K, Ander BP, Ghiasvand R, Zhan X, Stamova B, Jickling GC, Lyeth BG. Inhibition of Src Family Kinases Protects Hippocampal Neurons and Improves Cognitive Function after Traumatic Brain Injury. J Neurotrauma 311268-1276, 2014.

Wang T, Huang X-J, Van KC, Went G, Nguyen J, Lyeth BG. Repeated post-injury dosing with amantadine improves cognitive outcome and increases neuronal survival after fluid percussion TBI in rats. J Neurotrauma 31:370-377, 2014.

Russell M, Goodman T, Wang Q, Groshong B, Lyeth BG. Gender differences in current received during transcranial electrical stimulation. Frontiers in Psychiatry 5 (article 104): 1-7, 2014.

Gurkoff GG, Feng JF, Van KC, Izadi1 A, Ghiasvand R, Shahlaie K, Song M, Lowe DA, Zhou J, Lyeth BG. NAAG Peptidase Inhibitor Improves Motor Function and Reduces Cognitive Dysfunction in a Model of TBI with Secondary Hypoxia. Brain Research 1515:98-107, 2013.

Shahlaie K, Gurkoff GG, Lyeth BG, Muizelaar JP, Berman RF. Neuroprotective effects of SNX-185 treatment in an In Vitro Model of TBI with Secondary Hypoxia.  Restorative Neurology & Neuroscience 31(2): 141-153, 2013.

Lee DJ, Gurkoff GG, Izadi, A, Berman RF, Ekstrom AD, Muizelaar JP, Lyeth BG, Shahlaie K. Medial septal nucleus theta frequency deep brain stimulation improves spatial working memory following traumatic brain injury. J Neurotrauma 30: 131-139, 2013.

Gurkoff GG, Gahan JD, Ghiasvand RT, Hunsaker MR, Van K, Feng J-F, Shahlaie K, Berman RF, Lyeth BG, Folkerts MM. Evaluation of metric, topological and temporal ordering memory tasks after lateral fluid percussion injury. J Neurotrauma  30(4): 292-300, 2013.

Feng, J-F, Gurkoff GG, Van KC, Song M, Lowe DA, Zhou J, Lyeth BG. NAAG peptidase inhibitor reduces cellular damage in a model of TBI with secondary hypoxia. Brain Research 1469:144-152, 2012.

Gurkoff, GG, Shahlaie K, Lyeth BG. In vitro mechanical strain trauma alters neuronal calcium responses: Implications for post-traumatic epilepsy. Epilepsia 53(Suppl. 1):53-60, 2012.

Feng, J-F, Zhao, X-R, Van, KC, Shahlaie, K, Gurkoff, GG, Lyeth, BG.  Posttraumatic hypoxia exacerbates neuronal cell death in the hippocampus. J Neurotrauma 29(4):1167-1179, 2012.


Department of Neurological Surgery

Center for Neuroscience

Pharmacology and Toxicology