Lee-Way Jin, M.D., Ph.D.

 Lee-Way  Jin, M.D., Ph.D.

Faculty

  • Professor
  • Pathology and Laboratory Medicine

Contact

Alzheimer’s Disease, Autism Spectrum Disorders, Glia Biology

Research Summary

1. Development of small molecule compounds that inhibit the aggregation and toxicity of amyloid-beta oligomers as a potential therapy for Alzheimer's disease; Using these compounds and other probes to study the mechanism of amyloid-beta toxicity.

2. The influence of lipoprotein metabolism on amyloid-beta aggregation, focusing on the effect of brain phospholipid transfer protein.

3. Neuropathological studies of autism spectrum disorders and related neurodevelopmental disorders.

Teaching Interests:
Alzheimer's disease, pathology of neurodegenerative disorders

Select Publications

1. Shie FS, Jin L-W, Leverenz JB, LeBoeuf RC (2002) Diet-induced hypercholesterolemia enhances accumulation of Abeta in a mouse model of Alzheimers disease. NeuroReport 13:455-459.

2. Xu J, Kao S-Y, Lee FJ, Song W, Jin L-W, Yankner BA (2002) Dopamine-dependent neurotoxicity of native alpha-synuclein: a mechanism for selective neurodegeneration in Parkinsons disease. Nature Medicine 8:600-606.

3. Jin L-W, Hua DH, Shie F-S, Maezawa I, Sopher B, Martin GM (2002) Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death. J Mol Neurosci 19:57-61.

4. Maezawa I, Wang B, Hu Q, Martin GM, Jin L-W, Oshima J (2002) Alterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicity. Pathol Int 52:551-554.

5. Bu B, Klunemann H, Suzuki K, Li J, Bird T, Jin L-W, Vincent I (2002) Niemann-Pick disease type C yields possible clue for why cerebellar neurons do not form neurofibrillary tangles. Neurobiol Dis 11:285-297.

6. Kurimoto M, Müller B, Kaminsky W, Kahr B, Jin L-W (2002) Dyeing Crystals to Dyeing Tissues: Congo Red in Anisotropic Media. Molecular Crystals and Liquid Crystals 389:1-9.

7. Cook DG, Leverenz JB, Ericksen S, Roth RA, Schellenberg GD, Jin L-W, Kovacina KS, Craft S (2003) Reduced hippocampal insulin degrading enzyme in late onset Alzheimers disease is associated with the apolipoprotein E-epsilon4 allele. Am J Pathol 162:313-319.

8. Brich J, Shie F-S, Howell BW, Li R, Tus K, Wakeland EK, Jin L-W, Mumby M, Churchill G, Herz J, Cooper JA (2003) Genetic modulationof tau phosphorylation in the mouse. J Neurosci 23:187-192.

9. Shie FS, LeBoeuf RC, Jin L-W (2003) Early intraneuronal Abeta deposition in the CA1 of APP transgenic mice. NeuroReport 14:123-129.

10. Vuletic S, Jin L-W, Marcovina SM, Peskind ER, Müller T, Albers JJ (2003) Widespread distribution of plasma phospholipids transfer protein in human central nervous system: evidence for PLTP synthesis by glia and neurons and for altered PLTP distribution in Alzheimers disease. J Lipid Res, 44:1113-1123.

11. Hua DH, Huang X, Tamura M, Chen Y, Woltkamp M, Jin L-W, Perchellet EM, Perchellet J-P, Chiang PK, Namatame I, Tomoda H. (2003) Synthesis and bioactivities of tricyclic pyrones. Tetrahedron, 59:4795-4803.

12. Kung MP, Zhuang ZP, Hou C, Jin L-W, Kung HF. (2003) Characterization of radioiodinated ligand binding to amyloid beta plaques. J Mol Neurosci 20:249-254.

13. Jin L-W, Claborn K, Kurimoto M, Geday M, Maezawa I, Sohraby F, Estrada M, Kaminsky W, Kahr B. (2003) Linear birefringence and dichroism imaging of amyloid plaques. Proc Nat Acad Sci USA, 100:15294-15298.

14. Wang B, Hu Q, Hearn MG, Shimizu K, Jin L-W, Ware CB, Liggit DH, Cool BH, Storm DR, Martin GM. Isoform specific knockout of FE65 leads to impaired learning and memory. J Neurosci Res, 75:12-24.

15. Jin L-W, Maezawa I, Vincent I, Bird T. (2004) Intracellular accumulation of amyloidogenic fragments of APP in neurons with Niemann-Pick type C defects is associated with early endosomal abnormalities. Am J Pathol, 164:975-985.

16. Sopher BL, Thomas PS Jr, LaFevre-Bernt MA, Holm IE, Wilke SA, Ware CB, Jin L-W, Libby RT, Ellerby LM, La Spada AR. (2004) Androgen Receptor YAC Transgenic Mice Recapitulate SBMA Motor Neuronopathy and Implicate VEGF164 in the Motor Neuron Degeneration. Neuron 41:687-699.

17. Kaminsky W, Jin L-W, Powell S, Maezawa I, Claborn K, Kahr B. Polarimetric microscopic imaging of amyloid. Micron, in press.eda N, Martin GM, Montine TJ, Montine KS. (2004) Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carbosy terminal fragment-associated cytotoxicity. J Neurochem, 91:1312-1321.

19. Vuletic S, Peskind ER, Marcovina SM, Quinn JF, Cheung MC, Kennedy H, Kaye JA, Jin L-W, and Albers JJ. Reduced CSF PLTP activity in Alzheimers disease and

Affiliations

Pathology MIND Institute Neuroscience