Andrew S. Fox, Ph.D.

 Andrew S.  Fox, Ph.D.

Position

  • Assistant Professor
  • Psychology

The neuroscience of emotion and temperament in primates

Research Summary

In the Fox lab, we want to understand the neurobiology of “affective style”. We want to understand why some people are afraid to leave the house, while others enjoy the feeling of danger. We want to understand why some people callously abuse, while others become overwhelmed with empathy. We hope that understanding the biology of affective style will lead us to a better understand humanity and help people make choices about who they want to be.

Much of our research aims to understand the biology that underlies dispositional anxiety. This kind of understanding could allow for specific interventions to ameliorate anxiety disorders and reduce the suffering of anxious individuals. To do this, we use varied tools to study humans and nonhuman primates, including: high-throughput computing, neuroimaging, RNA-sequencing, cellphone-based experience sampling, and designer receptors exclusively activated by designer drugs.

The Fox lab for Translational Affective Neuroscience aims to foster principles of innovation, integration, and collaboration in conducting rigorous and open science.

Visit the Foxlab website to learn more: http://foxlab.ucdavis.edu

Selected Publications

Fox AS, Oler JA, Tromp DPM, Fudge J, & Kalin NH (2015). Extending the amygdala in theories of threat processing. Trends in Neurosciences. 38(5)                     

Fox AS, Oler JA, Shackman AJ, Shelton SE, Raveendran M, McKay DR, Converse AK, Alexander AL, Davidson RJ, Blangero J, Rogers J, & Kalin NH (2015). Intergenerational neural mediators of early-life anxious temperament. Proceedings of the National Academy of Sciences. 112(29):9118-9122

Fox AS & Kalin NH (2014). A Translational Neuroscience Approach to Understanding the Development of Social Anxiety Disorder and Its Pathophysiology. American Journal of Psychiatry. 171(11):1162–1173

Kalin NH, Fox AS, Kovner R, Riedel MK, Feketa EM, Roseboom PH, Tromp DPM, Grabow BP, Brodsky EK, Olsen ME, Alexander AL, Emborg ME, Block WF, Fudge JL, Oler JA (2016). Overexpressing Corticotropin-releasing hormone (CRH) in the primate amygdala increases anxious temperament and alters its neural circuit. Biological Psychiatry. 80(5):345-355.

Fox AS, Oler JA, Shelton SE, Nanda SA, Davidson RJ, Roseboom PH, Kalin NH (2012). Central amygdala nucleus (Ce) gene expression linked to increased trait-like Ce metabolism and anxious temperament in young primates. Proceedings of the National Academy of Sciences. 109(44):18108–18113

A complete list of publications can be found on the Fox Lab website (foxlab.ucdavis.edu/categories/publications/), or on google scholar (https://scholar.google.com/citations?hl=en&user=oJ-tGWYAAAAJ)

Affiliations

Psychology

Core Scientist, California National Primate Research Center